Role of STAT3 in skin fibrosis and transforming growth factor beta signalling
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology"
DOI: 10.1093/rheumatology/kex347
Abstract: Objective SSc is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. IL-6 and related cytokines that signal through STAT3 have been implicated in the pathogenesis of SSc and mouse models… read more here.
Keywords: mouse models; fibrosis; role stat3; stat3 ... See more keywords
Key Role of STAT3 in Osteoarthritis: From Pathogenic Mechanisms to Targeted Therapy
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s558209
Abstract: Abstract Osteoarthritis (OA) is a multifactorial degenerative disease characterized by articular cartilage degeneration. Currently, the underlying mechanisms of its pathogenesis remain unclear, and effective treatment options are limited. Signal transducer and activator of transcription 3… read more here.
Keywords: key role; stat3 osteoarthritis; osteoarthritis pathogenic; role stat3 ... See more keywords
Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2025.1608612
Abstract: Cancer cachexia is a complex, multifactorial syndrome characterized by severe weight loss, muscle wasting, and systemic inflammation, significantly contributing to cancer-related morbidity and mortality. Signal transducer and activator of transcription 3 (STAT3) has emerged as… read more here.
Keywords: cancer; unraveling role; role stat3; cancer cachexia ... See more keywords
The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947568
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a member of the Janus kinase (JAK)-STAT pathway, which is one of the key pathways contributing to cancer. STAT3 regulates transcription downstream of many cytokines including… read more here.
Keywords: cell; surveillance; role stat3; stat3 ... See more keywords
Advances in the role of STAT3 in macrophage polarization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1160719
Abstract: The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number… read more here.
Keywords: advances role; macrophage polarization; role stat3; stat3 macrophage ... See more keywords
Role of STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1021179
Abstract: Nasopharyngeal carcinoma (NPC) is a type of head and neck tumor with noticeable regional and ethnic differences. It is associated with Epstein-Barr virus infection and has a tendency for local and distant metastasis. NPC is… read more here.
Keywords: nasopharyngeal carcinoma; role stat3; stat3 pathogenesis; stat3 ... See more keywords
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22020603
Abstract: Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as… read more here.
Keywords: stat3 cancer; multifaced role; role stat3; stat3 ... See more keywords