On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunologic research"
DOI: 10.1007/s12026-019-09089-5
Abstract: Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess… read more here.
Keywords: immunoregulatory role; multiple sclerosis; th17 cells; role statins ... See more keywords
The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-018-0110-3
Abstract: Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized controlled trials… read more here.
Keywords: statins cognitive; role statins; cognitive impairment; impairment ... See more keywords
The role of statins as therapeutic agents in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "General physiology and biophysics"
DOI: 10.4149/gpb_2017045
Abstract: Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This enzyme catalyzes conversion of HMG-CoA to mevalonate, which are the intermediates in cholesterol biosynthetic pathway. Statins also play an important role in carcinogenesis, because… read more here.
Keywords: role statins; statins therapeutic; agents cancer; role ... See more keywords