Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing
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DOI: 10.3389/fimmu.2018.00529
Abstract: The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1,… read more here.
Keywords: cytotoxic; role stxbp1; allelic mutations; mutations stxbp2 ... See more keywords