Rnr1’s role in telomere elongation cannot be replaced by Rnr3: a role beyond dNTPs?
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DOI: 10.1007/s00294-017-0779-3
Abstract: Telomeres, the nucleoprotein complexes at the end of eukaryotic chromosomes, protect them from degradation and ensure the replicative capacity of cells. In most human tumors and in budding yeast, telomere length is maintained by the… read more here.
Keywords: role telomere; elongation; role; short telomeres ... See more keywords
The role of telomere binding molecules for normal and abnormal hematopoiesis
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DOI: 10.1007/s12185-018-2432-4
Abstract: In order to maintain the homeostasis of the hematopoietic system, hematopoietic stem cells (HSCs) need to be maintained while slowly dividing over their lifetime. However, repeated cell divisions lead to the gradual accumulation of DNA… read more here.
Keywords: role telomere; normal abnormal; role; binding molecules ... See more keywords
Understanding the role of telomere attrition and epigenetic signatures in COVID-19 severity
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DOI: 10.1016/j.gene.2021.146069
Abstract: Within the past several decades, the emergence and spread of infectious diseases with pandemic potential have endangered human lives. Coronavirus disease 2019 (COVID-19) outbreak represents an unprecedented threat for all health systems worldwide. The clinical… read more here.
Keywords: telomere length; covid; understanding role; role ... See more keywords
Role of telomere length in human carcinogenesis (Review).
Sign Up to like & getrecommendations! Published in 2023 at "International journal of oncology"
DOI: 10.3892/ijo.2023.5526
Abstract: Cancer is considered the most important clinical, social and economic issue regarding cause‑specific disability‑adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific… read more here.
Keywords: telomere length; role telomere; review; carcinogenesis ... See more keywords