Determining the Role of N-Terminal Acetylation on α-Synuclein Function
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1982
Abstract: α-Synuclein (αS) is an abundant neuronal protein implicated in Parkinson's disease. Acetylation of the N-terminal methionine of αS is a ubiquitous modification of αS derived from healthy brain tissue as well as from Parkinson's disease… read more here.
Keywords: role terminal; acetylation; synuclein; terminal acetylation ... See more keywords
The role of PA-X C-terminal 20 residues of classical swine influenza virus in its replication and pathogenicity.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2020.108916
Abstract: PA-X is a fusion protein encoded by a +1 frameshifted open reading frame (X-ORF) in PA gene. The X-ORF can be translated in full-length (61 amino acids, aa) or truncated (41 aa) form. However, the… read more here.
Keywords: role terminal; influenza; replication pathogenicity; replication ... See more keywords
Role of C terminal binding proteins (CtBP) in pancreatic adenocarcinoma (PDAC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.320
Abstract: 320Background: Overexpression of the oncogenic transcription factors CtBP1 and 2 is common and associated with poor prognosis in ovarian, breast and prostate cancer. CtBP2 drives tumor progression through promotion of epithelial-mesenchymal transition (EMT) and cancer… read more here.
Keywords: role terminal; binding proteins; pdac; proteins ctbp ... See more keywords
Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells
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DOI: 10.3390/ijms23063313
Abstract: Voltage-gated Kv1.3 potassium channels are essential for maintaining negative membrane potential during T-cell activation. They interact with membrane-associated guanylate kinases (MAGUK-s) via their C-terminus and with TCR/CD3, leading to enrichment at the immunological synapse (IS).… read more here.
Keywords: non conducting; mobility; membrane potential; kv1 ... See more keywords