A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin
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DOI: 10.1038/s41598-018-26764-z
Abstract: Botulinum neurotoxin (BoNT) is responsible for botulism, a clinical condition resulting in flaccid muscle paralysis and potentially death. The light chain is responsible for its intracellular toxicity through its endopeptidase activity. Available crystal structures of… read more here.
Keywords: botulinum neurotoxin; structure; role terminus; activity ... See more keywords