The role and therapeutic potential of MSC-derived exosomes in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.109002
Abstract: Osteoarthritis (OA) is the most common painful disease with chronic articular cartilage degeneration. The pathological process of OA is complex and characterized by the imbalance between the synthesis and catabolism of chondrocytes and extracellular matrix,… read more here.
Keywords: role therapeutic; therapeutic potential; msc derived; derived exosomes ... See more keywords
The role and therapeutic potential of exosomes in ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105194
Abstract: Ischemic stroke is a disease caused by insufficient blood and oxygen supply to the brain, which is mainly due to intracranial arterial stenosis and middle cerebral artery occlusion. Exosomes play an important role in cerebral… read more here.
Keywords: role therapeutic; therapeutic potential; ischemic stroke; cerebral ischemia ... See more keywords
New insights into the role and therapeutic potential of HSP70 in diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106173
Abstract: Emerging evidence indicates that HSP70 represents a key mechanism in the pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications, including micro- and macro-vascular alterations, as well as impaired hemostasis. Hyperglycemia, a hallmark of… read more here.
Keywords: therapeutic potential; insights role; role therapeutic; potential hsp70 ... See more keywords
O-glycosylation and its role in therapeutic proteins
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220094
Abstract: Abstract Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post translational modification with sophisticated carbohydrate structures plays a profound role in the interaction of proteins with cells and changes the physiochemical properties… read more here.
Keywords: glycosylation role; role; therapeutic proteins; role therapeutic ... See more keywords
Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac392
Abstract: Abstract A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma… read more here.
Keywords: therapeutic drug; infection; mycobacterium abscessus; role therapeutic ... See more keywords
The role and therapeutic applications of exosomes in multiple sclerosis disease
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13710
Abstract: A range of the central nervous system (CNS) and immune cells are affected by multiple sclerosis (MS), a complex autoimmune disease of the CNS. Chronic neuroinflammation, demyelination, and neuronal death are all features of MS,… read more here.
Keywords: sclerosis; disease; therapeutic applications; role therapeutic ... See more keywords
Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13797
Abstract: Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from… read more here.
Keywords: acute inflammatory; role therapeutic; biology; therapeutic potential ... See more keywords
Role of therapeutic plasma exchanges in refractory severe warm autoimmune hemolytic anemia: Presentation of two case reports
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion"
DOI: 10.1111/trf.16143
Abstract: Warm autoimmune hemolytic anemia (WAIHA) is a disorder with a usually good response to corticosteroid treatment, whereas in some cases first‐line treatment's response is poor and other therapies such as intravenous immunoglobulins (IVIGs), rituximab, or… read more here.
Keywords: hemolytic anemia; warm autoimmune; role therapeutic; autoimmune hemolytic ... See more keywords
The Role of the Therapeutic Relationship in Psychopharmacological Treatment Outcomes: A Meta-analytic Review.
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatric services"
DOI: 10.1176/appi.ps.201700114
Abstract: OBJECTIVE Patient nonadherence to psychopharmacological treatment is a significant barrier to effective treatment. The therapeutic relationship is known to be a critical component of effective psychological treatment, but it has received limited study. A meta-analysis… read more here.
Keywords: treatment outcomes; treatment; role therapeutic; therapeutic relationship ... See more keywords
Role and therapeutic potential of RAGE signaling in neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450123666220610171005
Abstract: Activation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Although… read more here.
Keywords: therapeutic potential; rage; role therapeutic; rage signaling ... See more keywords
Ferroptosis in sepsis: The mechanism, the role and the therapeutic potential
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.956361
Abstract: Sepsis is a common critical illness in the Intensive care unit(ICU) and its management and treatment has always been a major challenge in critical care medicine. The dysregulated host response to infection, causing systemic multi-organ… read more here.
Keywords: sepsis; mechanism role; role therapeutic; ferroptosis sepsis ... See more keywords