Identification of the novel G250R variant indicates a role for Thrombomodulin in modulating the risk for venous thromboembolism.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1827-7109
Abstract: Thrombomodulin displays anticoagulant properties through thrombin binding and protein C activation. In close relatives who had a history of recurrent VTE, a missense variant (G250R) in the EGF-1 domain was identified. In an asymptomatic 250R… read more here.
Keywords: role thrombomodulin; variant; g250r; thrombomodulin ... See more keywords
Role of thrombomodulin expression on hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14663
Abstract: Activation of protease‐activated receptor 1 (PAR1) by either thrombin or activated protein C (aPC) differentially regulate the quiescence and bone marrow (BM) retention of hematopoietic stem cells (HSC). Murine HSC co‐express THBD, PAR1, and endothelial… read more here.
Keywords: role thrombomodulin; thrombomodulin expression; hematopoietic stem; stem cells ... See more keywords