Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/2985051
Abstract: Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing… read more here.
Keywords: role tnf; pathology; amyotrophic lateral; role ... See more keywords
Editorial: The Role of TNF-TNFR2 Signal in Immunosuppressive Cells and Its Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02126
Abstract: TNF is generally believed to be a master pro-inflammatory cytokine, and anti-TNF therapy has become the mainstream treatment for some autoimmune diseases. However, experimental evidence indicates that TNF preferentially activates Tregs, resulting in their proliferation,… read more here.
Keywords: tnf; editorial role; tnfr2 signal; tnf tnfr2 ... See more keywords
Dual Role of TNF and LTα in Carcinogenesis as Implicated by Studies in Mice
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DOI: 10.3390/cancers13081775
Abstract: Simple Summary Tumor necrosis factor (TNF) and its closely related cytokine, lymphotoxin alpha (LTα), are part of the TNF superfamily and exert their functions via both overlapping and non-redundant signaling pathways. Reported pro- and antitumorigenic… read more here.
Keywords: tnf; dual role; tnf carcinogenesis; role tnf ... See more keywords
Behҫet’s Disease, and the Role of TNF-α and TNF-α Blockers
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DOI: 10.3390/ijms21093072
Abstract: In this both narrative and systematic review, we explore the role of TNF-α in the immunopathogenesis of Behçet’s disease (BD) and the effect of treatment with TNF-α blockers. BD is an auto-inflammatory disease, characterized by… read more here.
Keywords: tnf; tnf blockers; treatment; role tnf ... See more keywords
Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137191
Abstract: The neuroimmune mechanism underlying neuropathic pain has been extensively studied. Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine storm and stimulates a cascade of other cytokines in pain-related pathways, induces and modulates… read more here.
Keywords: role tnf; necroptosis; neuropathic pain; pain ... See more keywords