Neurodegeneration in ataxia‐telangiectasia: Multiple roles of ATM kinase in cellular homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24522
Abstract: Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes, immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the deficiency of the protein kinase coded by the ATM (ataxia‐telangiectasia mutated) gene. ATM… read more here.
Keywords: roles atm; ataxia telangiectasia; cellular homeostasis;
Publisher's Note: Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.259033
Abstract: Cells exposed to genotoxic stress induce cellular senescence through a DNA damage response (DDR) pathway regulated by ATM kinase and reactive oxygen species (ROS). Here, we show that the regulatory roles for ATM kinase and… read more here.
Keywords: cellular senescence; genotoxic stress; induction maintenance; roles atm ... See more keywords