Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03238-7
Abstract: Claudins are a family of integral tight junction proteins that regulate paracellular permeability in polarized epithelia. Overexpression or reduction of claudins can both promote and limit cancer progression, revealing complex dichotomous roles for claudins depending… read more here.
Keywords: knockout mice; cancer; roles claudins; dichotomous roles ... See more keywords
Context-Dependent Roles of Claudins in Tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.676781
Abstract: The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated… read more here.
Keywords: roles claudins; claudins tumorigenesis; context dependent; dependent roles ... See more keywords