Roles of pH and the Na+/H+ exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?
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DOI: 10.1016/j.semcancer.2016.12.001
Abstract: Acidosis is characteristic of the solid tumor microenvironment. Tumor cells, because they are highly proliferative and anabolic, have greatly elevated metabolic acid production. To sustain a normal cytosolic pH homeostasis they therefore need to either… read more here.
Keywords: exchanger nhe1; roles exchanger; animal models; biology ... See more keywords