Critical roles of m6A methylation in cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1187514
Abstract: Cardiovascular diseases (CVDs) have been established as a major cause of mortality globally. However, the exact pathogenesis remains obscure. N6-methyladenosine (m6A) methylation is the most common epigenetic modification on mRNAs regulated by methyltransferase complexes (writers),… read more here.
Keywords: methylation; critical roles; m6a methylation; cardiovascular diseases ... See more keywords
Multiple Roles of m6A RNA Modification in Translational Regulation in Cancer
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DOI: 10.3390/ijms23168971
Abstract: Despite its discovery in the early 1970s, m6A modification within mRNA molecules has only powerfully entered the oncology field in recent years. This chemical modification can control all aspects of the maturation of mRNAs, both… read more here.
Keywords: m6a rna; modification; multiple roles; regulation ... See more keywords
Emerging Mutual Regulatory Roles between m6A Modification and microRNAs
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010773
Abstract: N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on… read more here.
Keywords: modification; m6a modification; regulatory roles; regulatory proteins ... See more keywords
Potential Roles of m6A and FTO in Synaptic Connectivity and Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076220
Abstract: RNA modifications known as epitranscriptomics have emerged as a novel layer of transcriptomic regulation. Like the well-studied epigenetic modifications characterized in DNA and on histone-tails, they have been shown to regulate activity-dependent gene expression and… read more here.
Keywords: synaptic connectivity; m6a fto; depressive disorder; roles m6a ... See more keywords
Roles of m6A modification in oral cancer (Review)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5453
Abstract: Oral cancer is one of the highly malignant tumors with poor prognosis. The pathogenic mechanisms of oral cancer have remained to be fully elucidated and this brings significant challenges to the treatment. RNA modification is… read more here.
Keywords: modification; m6a modification; review; oral cancer ... See more keywords