Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses
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DOI: 10.1021/acs.jmedchem.2c00697
Abstract: From a designed library of indolyl pyrimidinamines, we identified a highly potent and cell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve). Comprehensive evaluation of inhibitor selectivity confirmed that this PIKfyve probe demonstrates excellent kinome-wide… read more here.
Keywords: roles pikfyve; chemical probe; lifecycle coronaviruses; identification utilization ... See more keywords