Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.04.011
Abstract: Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism… read more here.
Keywords: tumor progression; roles protein; important roles; protein tyrosine ... See more keywords
Mechanistic roles of protein disorder within transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.02.003
Abstract: Understanding the interactions of proteins involved in transcriptional regulation is critical to describing biological systems because they control the expression profile of the cell. Yet sadly they belong to a less well biophysically characterized subset… read more here.
Keywords: roles protein; mechanistic roles; protein disorder; biology ... See more keywords
Unraveling the Roles of Protein Kinases in Autophagy: An Update on Small-Molecule Compounds for Targeted Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02053
Abstract: Protein kinases, which catalyze the phosphorylation of proteins, are involved in several important cellular processes, such as autophagy. Of note, autophagy, originally described as a mechanism for intracellular waste disposal and recovery, has been becoming… read more here.
Keywords: small molecule; protein kinases; roles protein; molecule compounds ... See more keywords
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221317
Abstract: G protein-coupled receptors (GPCRs) are key modulators of cell signaling. Multiple GPCRs are present in the heart where they regulate cardiac homeostasis including processes such as myocyte contraction, heart rate and coronary blood flow. GPCRs… read more here.
Keywords: coupled receptor; novel roles; roles protein; heart ... See more keywords
The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14060402
Abstract: In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulation of a plethora of endogenous waste molecules that cannot be removed by current dialysis techniques, the most often applied treatment. These… read more here.
Keywords: protein bound; solutes toxins; roles protein; bound solutes ... See more keywords
Pivotal roles of protein 4.1B/DAL-1, a FERM-domain containing protein, in tumor progression (Review)
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Oncology"
DOI: 10.3892/ijo.2019.4935
Abstract: Following the publication of this article, the authors have realized that the grant number published in the 'Funding' section associated with the support that they received from the Changzhou Sci&Tech Program ('20180170') was incorrect: This was… read more here.
Keywords: pivotal roles; roles protein; protein dal; number ... See more keywords
Emerging roles of protein disulfide isomerase in cancer
Sign Up to like & getrecommendations! Published in 2017 at "BMB Reports"
DOI: 10.5483/bmbrep.2017.50.8.107
Abstract: The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins.… read more here.
Keywords: roles protein; disulfide isomerase; emerging roles; protein disulfide ... See more keywords
Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.72244
Abstract: Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoylation is crucial for many tumor-related signaling pathways, such… read more here.
Keywords: palmitoylation modifying; roles protein; modifying enzymes; protein palmitoylation ... See more keywords