Emerging roles of and therapeutic strategies targeting BRD4 in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2019.02.001
Abstract: The Bromodomain and Extra-terminal (BET) family of proteins were first recognized as important epigenetic regulators in inflammatory processes; however, there is increasing evidence to support the notion that BET proteins also play a critical role… read more here.
Keywords: bet proteins; emerging roles; strategies targeting; therapeutic strategies ... See more keywords
Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/2570154
Abstract: Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases… read more here.
Keywords: revisited roles; proteases revisited; fibrosis; implications fibrosis ... See more keywords
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/2931813
Abstract: Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be… read more here.
Keywords: hepatocellular carcinoma; therapeutic applications; exosomes hepatocellular; functional roles ... See more keywords
Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/9068850
Abstract: Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events.… read more here.
Keywords: hepatocellular carcinoma; compounds hepatocellular; bioactive compounds; roles therapeutic ... See more keywords
Hydrogen sulfide: physiological roles and therapeutic implications against COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230502111227
Abstract: The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host… read more here.
Keywords: sulfide physiological; physiological roles; roles therapeutic; implications covid ... See more keywords
RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00438
Abstract: The well-known signal mediator and small GTPase family member, RHOA, has now been associated with the progression of specific malignancies. In this review, we appraise the biomedical literature regarding the role of this enzyme in… read more here.
Keywords: rhoa gastric; gastric cancer; cancer functional; functional roles ... See more keywords
Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.979370
Abstract: Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in… read more here.
Keywords: therapeutic potential; cells inflammatory; nkt cells; inflammatory skin ... See more keywords