Using a Model-based Material Sparing Approach for Formulation and Process Development of a Roller Compacted Drug Product.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical research"
DOI: 10.1007/s11095-022-03192-3
Abstract: The present work details a material sparing approach that combines material profiling with Instron uniaxial die-punch tester and use of a roller compaction mathematical model to guide both formulation and process development of a roller-compacted… read more here.
Keywords: roller; roller compacted; drug; roller compaction ... See more keywords
Improving feeding powder distribution to the compaction zone in the roller compaction
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.04.015
Abstract: Graphical abstract Figure. No caption available. Abstract In the roller compaction process, powder flow properties have a significant influence on the uniformity of the ribbon properties. The objective of this work was to improve the… read more here.
Keywords: roller; feeding guiders; roller compaction; powder ... See more keywords
Use of roller compaction and fines recycling process in the preparation of erlotinib hydrochloride tablets
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.01.036
Abstract: &NA; This study focuses on improving the manufacturing process for a generic immediate‐release tablet containing erlotinib hydrochloride by adding a fines recycling process during roller compaction. Due to the large fraction of small‐sized API particles,… read more here.
Keywords: recycling process; process; fines recycling; roller compaction ... See more keywords
Simplifying Johanson's Roller Compaction Model to Build a "Virtual Roller Compactor" as a Predictive Tool - Theory and Practical Application.
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DOI: 10.1016/j.ijpharm.2021.120579
Abstract: The purpose of the study is to build a "virtual roller compactor" as a predictive tool to assess the roll force (RF)-maximum pressure (Pmax) and RF-ribbon density relationship for pharmaceutical roller compaction. We provided a… read more here.
Keywords: model; roller compaction; predictive tool; roller ... See more keywords
Linking API brittleness in high load formulations to the roller compaction process
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DOI: 10.1016/j.powtec.2018.01.023
Abstract: Abstract There is considerable interest in formulations with high active pharmaceutical ingredient (API) load, for reasons including lower patient tablet burden and therefore, potentially improved patient adherence. This remains a challenge not least because most… read more here.
Keywords: roll force; high load; roller compaction; process ... See more keywords
Comparative binder efficiency modeling of dry granulation binders using roller compaction
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DOI: 10.1080/03639045.2016.1272118
Abstract: Abstract Roller compaction parameters’ impact on granules and tableting properties of coprocessed Avicel® DG [ADG], a physical mixture of the two components at the same composition present in ADG [PADCP], and microcrystalline cellulose and Kollidon®… read more here.
Keywords: roller compaction; tablet; physical mixture; roller ... See more keywords
Modification of α-lactose monohydrate as a direct compression excipient using roller compaction
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DOI: 10.1080/03639045.2018.1508224
Abstract: Abstract Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted… read more here.
Keywords: roller compaction; excipient; compaction; lactose monohydrate ... See more keywords