HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration
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DOI: 10.1038/s41598-019-43230-6
Abstract: Tissue regeneration is associated with complex changes in gene expression and post-translational modifications of proteins, including transcription factors and histones that comprise chromatin. We tested 172 compounds designed to target epigenetic mechanisms in an axolotl… read more here.
Keywords: transcription; hdac regulates; tail regeneration; regeneration ... See more keywords
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002083
Abstract: Objectives: Reversing HIV-1 latency has been suggested as a strategy to eradicate HIV-1. We investigated the effect of romidepsin on the HIV transcription profile in participants from the REDUC part B clinical trial. Design: Seventeen… read more here.
Keywords: romidepsin; hiv; hiv transcription; transcription profile ... See more keywords
Romidepsin in combination with low‐dose methotrexate in advanced‐stage mycosis fungoides and Sézary syndrome
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DOI: 10.1111/dth.14952
Abstract: Dear Editor Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), accounting for 55% of cases. Sézary syndrome (SS) is a rare leukemic variant of CTCL. Skin-directed therapies are appropriate… read more here.
Keywords: combination; low dose; dose methotrexate; advanced stage ... See more keywords
Romidepsin Plus Liposomal Doxorubicin Is Safe and Effective in Patients with Relapsed or Refractory T-Cell Lymphoma: Results of a Phase I Dose-Escalation Study
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DOI: 10.1158/1078-0432.ccr-19-2152
Abstract: Purpose: The histone deacetylase (HDAC) inhibitor romidepsin and the anthracycline liposomal doxorubicin (LD) have modest single-agent activity in cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL). We investigated the safety and efficacy of the… read more here.
Keywords: cell lymphoma; romidepsin; romidepsin plus; cell ... See more keywords
Abstract 1329: Combination treatment with CB-839 and romidepsin induces apoptosis and suppresses cell viability in preclinical models of chondrosarcoma
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DOI: 10.1158/1538-7445.am2018-1329
Abstract: Chondrosarcomas are the second most frequently occurring type of bone malignancy, and account for approximately 25% of all bone sarcomas. They are often highly aggressive neoplasms that rapidly progress and eventually recur and give distant… read more here.
Keywords: combination; viability; treatment; combination treatment ... See more keywords
Abstract 1996: Prostate cancer androgen receptor signaling inhibition via romidepsin encapsulated lipid-polymer hybrid nanoparticle with PSMA617 targeting
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1996
Abstract: Purpose/Objective(s): Androgen deprivation therapy (ADT) has been a clinical standard of care for the treatment of castration sensitive prostate cancer (CSPC). However, it is not curative, and ADT has significant systemic effects including hot flashes,… read more here.
Keywords: cell; prostate cancer; nanoparticle; pca ... See more keywords
A real-world experience of combined treatment with romidepsin and azacitidine in patients with peripheral T-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.16_suppl.e19550
Abstract: e19550 Background: Patients with peripheral T-cell lymphoma (PTCL) lack good treatment options, particularly in the relapsed and refractory setting. Our work suggested that epigenetic therapies can be safe and effective for patients with PTCL, particularly… read more here.
Keywords: cell; world; cell lymphoma; romidepsin ... See more keywords
Efficacy and Treatment-Related Adverse Events of Romidepsin in PTCL Clinical Studies: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fmed.2021.732727
Abstract: Background: Peripheral T-cell lymphoma (PTCL) is an extensive class of biologically and clinically heterogeneous diseases with dismal outcomes. The histone deacetylase inhibitor (HDACi) romidepsin was approved for relapsed and refractory (R/R-PTCL) in 2011. This meta-analysis… read more here.
Keywords: romidepsin ptcl; adverse events; ptcl; efficacy ... See more keywords