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Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15176
Abstract: AIM Ropeginterferon alfa-2b is a novel, long-acting pegylated interferon alfa-2b. We aimed to evaluate its safety, pharmacokinetics (PK) and pharmacodynamics (PD). METHODS Thirty-six subjects received single subcutaneous injection of ropeginterferon alfa-2b at doses ranging 24-270…
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Keywords:
safety;
pegylated ifn;
ropeginterferon alfa;
ifn alfa ... See more keywords
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Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15376
Abstract: Although ropeginterferon alfa‐2b has recently been clinically applied to myeloproliferative neoplasms with promising results, its antitumor mechanism has not been thoroughly investigated. Using a leukemia model developed in immunocompetent mice, we evaluated the direct cytotoxic…
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Keywords:
ropeginterferon alfa;
alfa cancer;
mice;
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Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.320.320
Abstract: Background: Interferon-alpha (IFNa) based therapies have been successfully used in myeloproliferative neoplasms (MPN) for over thirty years. Ropeginterferon alfa-2b (Ropeg) is a novel mono-pegylated IFNa, which is administered once every 2 weeks, or monthly during…
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Keywords:
bat;
treatment;
year;
research funding ... See more keywords
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Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0596
Abstract: Patients diagnosed with high-risk essential thrombocythemia (ET) have limited treatment options to reduce the risk of thrombosis and lessen the progression of the disease by targeting the molecular source. Hydroxyurea is the recommended treatment, but…
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Keywords:
essential thrombocythemia;
anagrelide second;
ropeginterferon alfa;
line ... See more keywords
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Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1109866
Abstract: Ropeginterferon alfa-2b is a novel, long-acting mono-pegylated proline-IFN-alpha-2b approved for treatment of polycythemia vera in adults, regardless of thrombotic risk level or treatment history. Clinical trial data indicate the dose and titration of ropeginterferon alfa-2b…
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Keywords:
ropeginterferon alfa;
dosing strategy;
alternative dosing;
ropeginterferon ... See more keywords