Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution.
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23489
Abstract: Two nanoformulations with mucoadhesive properties and brain-targeting mechanisms were designed to deliver the anti-Parkinson's drug, ropinirole hydrochloride (RH). In the first formulation, RH and the amphiphilic block copolymer methoxy poly(ethylene glycol)-b-poly(caprolactone) were assembled in a… read more here.
Keywords: administration; brain targeting; biodistribution; ropinirole hydrochloride ... See more keywords
Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: in vitro and ex vivo evaluation of efficacy and safety.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119776
Abstract: Nose-to-brain delivery is an attractive route for direct drug delivery to the central nervous system (CNS), avoiding hepatic first-pass metabolism and solving blood-brain barrier passage issues. Therefore, the aim of the present study was the… read more here.
Keywords: plga chit; delivery; ropinirole hydrochloride; plga ... See more keywords
Polysorbate 80 coated crosslinked chitosan nanoparticles of ropinirole hydrochloride for brain targeting
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.08.016
Abstract: Abstract Targeting ropinirole hydrochloride (R-HCl) to brain in effective amount may be a breakthrough in the treatment of Parkinson's disease due to its extensive first-pass metabolism in stomach after oral administration. The aim of the… read more here.
Keywords: polysorbate coated; chitosan nanoparticles; ropinirole hydrochloride; hcl ... See more keywords
Clinical Observation of Ropinirole Hydrochloride in the Treatment of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/3989770
Abstract: Parkinson's disease is a degenerative disease of the nervous system, which is more common in middle-aged and elderly people. Currently, the incidence of PD is increasing. The disease is a degenerative disease, which is irreversible… read more here.
Keywords: disease; hydrochloride treatment; parkinson disease; ropinirole hydrochloride ... See more keywords