ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
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DOI: 10.1016/j.celrep.2021.109834
Abstract: WNTs play key roles in development and disease, signaling through Frizzled (FZD) seven-pass transmembrane receptors and numerous co-receptors including ROR and RYK family receptor tyrosine kinases (RTKs). We describe crystal structures and WNT-binding characteristics of… read more here.
Keywords: structures suggest; ror ryk; receptor tyrosine; tyrosine kinases ... See more keywords