STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Human cell"
DOI: 10.1007/s13577-021-00582-4
Abstract: Gefitinib is known as epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) while an increasing number of patients with non-small cell lung cancer (NSCLC) are becoming resistant to EGFR-TKI. Therefore, innovative methods are urgently needed to… read more here.
Keywords: hcc827 cells; inhibitor; gefitinib; stat3 inhibitor ... See more keywords
ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70924-z
Abstract: ROR1 and ROR2 are receptor tyrosine kinases with altered expression in a range of cancers. Silencing ROR1 or ROR2 in different tumour types has been shown to inhibit proliferation and decrease metastatic potential. The aim… read more here.
Keywords: ror1 ror2; upregulated endometrial; endometrial cancer; ror1 ... See more keywords
Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF‐1α regulator
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.14825
Abstract: We previously reported that ROR1 is a crucial downstream gene for the TTF‐1/NKX2‐1 lineage‐survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indicates ROR1… read more here.
Keywords: lung adenocarcinoma; ror1; regulator; development ... See more keywords
Abstract 3102: Venetoclax resistance associates with high-level expression of ROR1 and cancer stemness in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-3102
Abstract: The BH3-mimetic venetoclax is highly cytotoxic for chronic lymphocytic leukemia (CLL) cells. Nonetheless, some patients (pts) fail to clear minimal residual disease (MRD) and develop progressive disease (PD) on venetoclax-based therapy (V-Rx). Acquisition of de… read more here.
Keywords: venetoclax; cancer; resistance; cll cells ... See more keywords
Abstract 1152: NKTR-255, a polymer-conjugated IL-15, dramatically improves ROR1 CAR-T cell persistence and anti-tumor efficacy in an autochthonous model of ROR1+ lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1152
Abstract: CAR-T cells have mediated remarkable clinical responses against hematological malignancies, but this success has yet to extend to solid tumors, where many factors in the tumor microenvironment (TME) inhibit their persistence and function. In a… read more here.
Keywords: nktr 255; tumor; car; ror1 ... See more keywords
Abstract LB218: Developing a bispecific anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb218
Abstract: Developing a bispecific anti-ROR1 Antibody Drug Conjugate for hematological and solid tumor treatment Receptor tyrosine kinase ROR1 is a type I transmembrane protein belongs to the ROR family members. ROR1 is a receptor for Wnt… read more here.
Keywords: anti ror1; ror1; hematological solid; drug conjugate ... See more keywords
ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129773
Abstract: Background: ROR1 - a receptor tyrosine kinase (RTK) - is essential for normal embryonic development, but is absent on most normal adult tissues. ROR1 is of importance of cell proliferation, differentiation, survival and metabolism. However,… read more here.
Keywords: mcl; inhibitor; small molecule; kan0441571c ... See more keywords
ROR1 - An Orphan Becomes Apparent.
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DOI: 10.1182/blood.2021014760
Abstract: Since its initial identification in 1992 as a possible class I cell-surface receptor without a known parent ligand, receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) has stimulated research, which has made apparent its significance in embryonic development… read more here.
Keywords: becomes apparent; ror1 orphan; ror1; orphan becomes ... See more keywords
Long noncoding RNA ROR1‑AS1 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/β-catenin/EMT signaling cascade in cervical cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202003_20656
Abstract: OBJECTIVE Several long noncoding RNAs (lncRNAs) display functional effects in the tumorigenesis and progression of cervical cancer (CC). We aimed to investigate the roles of lncRNA tyrosine protein kinase transmembrane receptor 1 antisense RNA 1… read more here.
Keywords: long noncoding; catenin; ror1 as1; cervical cancer ... See more keywords
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer
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DOI: 10.3390/cancers11050718
Abstract: Among all breast cancer types, basal-like breast cancer (BLBC) represents an aggressive subtype that lacks targeted therapy. We and others have found that receptor tyrosine kinase-like orphan receptor 1 (ROR1) is overexpressed in BLBC and… read more here.
Keywords: like breast; breast cancer; ror1; cancer ... See more keywords
Meta-Analysis of Survival Effects of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1)
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58121867
Abstract: Background and Objectives: Identification and targeting of membrane proteins in tumor cells is one of the key steps in the development of cancer drugs. The receptor tyrosine kinase-like orphan receptor (ROR) type 1 is a… read more here.
Keywords: meta analysis; survival; expression; ror1 ... See more keywords