ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70924-z
Abstract: ROR1 and ROR2 are receptor tyrosine kinases with altered expression in a range of cancers. Silencing ROR1 or ROR2 in different tumour types has been shown to inhibit proliferation and decrease metastatic potential. The aim… read more here.
Keywords: ror1 ror2; upregulated endometrial; endometrial cancer; ror1 ... See more keywords
Expression of ROR1 and ROR2 in Hairy Cell Leukemia Cells Enhances Constitutive Activation of ERK1/2 and Cancer Stemness
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DOI: 10.1182/blood-2024-210584
Abstract: Hairy cell leukemia (HCL) is a malignancy of B-cells that co-express CD19, CD20, CD11c, CD25, CD103, CD123, and CD200 (but not CD5, CD10, CD21, or CD23) and that harbor a V600E BRAF mutation, which promotes… read more here.
Keywords: ror1 ror2; hcl; cell; ror1 ... See more keywords
Dual targeting of ROR1 and ROR2 with glycoengineered antibodies elicits potent and selective immunotherapy in hairy cell leukemia
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DOI: 10.1182/blood-2025-2359
Abstract: Receptor tyrosine kinase-like orphan receptors 1 and 2 (ROR1 and ROR2) are oncoembryonic antigens aberrantly expressed on hairy cell leukemia (HCL) B cells and various other cancers, but absent from healthy B cells and postpartum… read more here.
Keywords: ror2; ror1 ror2; cell leukemia; ror1 ... See more keywords
Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis
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DOI: 10.18632/oncotarget.22559
Abstract: OBJECTIVE Elevated expression of the ROR1 and ROR2 Wnt receptors has been noted in both the tumour and stromal compartments of ovarian cancer patient tissue samples. In vitro studies have suggested these receptors play a… read more here.
Keywords: ror1 ror2; model; ovarian cancer; ror2 ... See more keywords