ROR2 promotes the epithelial-mesenchymal transition by regulating MAPK/p38 signaling pathway in breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29666
Abstract: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a tyrosine-protein kinase receptor highly implicated in the growth plate and cartilage development, which may be involved in epithelial-mesenchymal transition (EMT) in breast cancer (BC) cells. Although… read more here.
Keywords: mesenchymal transition; mapk p38; mcf; breast cancer ... See more keywords
miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-024-00762-y
Abstract: Medulloblastoma (MB), a prevalent pediatric central nervous system tumor, is influenced by microRNAs (miRNAs) that impact tumor initiation and progression. However, the specific involvement of miRNAs in MB tumorigenesis remains unclear. Using single-cell RNA sequencing,… read more here.
Keywords: ror2; progression; mir 194; 124 mir ... See more keywords
Noncanonical Wnt/Ror2 signaling regulates cell–matrix adhesion to prompt directional tumor cell invasion in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0055
Abstract: Cell–extracellular matrix (ECM) interactions represent fundamental exchanges during tumor progression, yet how particular signal-transduction factors prompt the conversion of tumor cells into migratory populations capable of systemic spread during metastasis remains elusive. We demonstrate that… read more here.
Keywords: cell; ror2; wnt; invasion ... See more keywords
ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab024
Abstract: Cellular senescence severely limits the research and the application of dental pulp stem cells (DPSCs). A previous study conducted by our research group revealed a close implication of ROR2 in DPSC senescence, although the mechanism… read more here.
Keywords: p21; dental pulp; ror2; senescence ... See more keywords
WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3003
Abstract: Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established. In a subset of prostate cancer organoid culture and xenograft models, inhibition… read more here.
Keywords: hippo pathway; ror2; yap1 activity; tumor ... See more keywords
ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2)/Planar Cell Polarity a New Pathway Controlling Endothelial Cell Polarity Under Flow Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.123.319106
Abstract: BACKGROUND Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially to laminar shear stress. Among the cell responses to laminar flow, EC polarization against the flow direction emerges as a key… read more here.
Keywords: cell; ror2; cell polarity; planar cell ... See more keywords
Dual targeting of ROR1 and ROR2 with glycoengineered antibodies elicits potent and selective immunotherapy in hairy cell leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2359
Abstract: Receptor tyrosine kinase-like orphan receptors 1 and 2 (ROR1 and ROR2) are oncoembryonic antigens aberrantly expressed on hairy cell leukemia (HCL) B cells and various other cancers, but absent from healthy B cells and postpartum… read more here.
Keywords: ror2; ror1 ror2; cell leukemia; ror1 ... See more keywords
First report of ROR2 directed therapy with a conditionally active antibody drug conjugate in advanced melanoma.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.3077
Abstract: 3077 Background: The receptor tyrosine-kinase like orphan receptors (ROR) are mediators of noncanonical WNT signaling and tissue patterning. ROR2 upregulation is observed in malignancy and has been implicated in metastasis. Development of ROR2 directed conditionally… read more here.
Keywords: report; ror2; ror2 directed; drug ... See more keywords
Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22559
Abstract: OBJECTIVE Elevated expression of the ROR1 and ROR2 Wnt receptors has been noted in both the tumour and stromal compartments of ovarian cancer patient tissue samples. In vitro studies have suggested these receptors play a… read more here.
Keywords: ror1 ror2; model; ovarian cancer; ror2 ... See more keywords
Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9081054
Abstract: We investigated the association of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression with clinicopathological features and oncologic outcomes in large urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) cohorts. Through… read more here.
Keywords: ror2 expression; expression; significance ror2; urothelial carcinoma ... See more keywords
Association between Wnt inhibitory factor 1 and receptor tyrosine kinase-like orphan receptor 2 protein expression and the clinical pathological significance in benign and malignant pancreatic lesions
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5704
Abstract: Pancreatic cancer is one of the most malignant types of tumor. It is important to elucidate the underlying molecular mechanisms of pancreatic tumorigenesis and to identify novel biomarkers as therapeutic targets of pancreatic cancer. In… read more here.
Keywords: protein; protein expression; benign; expression ... See more keywords