Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13209
Abstract: Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form of niacin (vitamin B3), is currently available as a supplement for maintaining general physiologic functions. NAM is a crucial regulator of… read more here.
Keywords: metabolism; supplement; triple negative; ros ... See more keywords
Markers for Mitochondrial ROS Status.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1653-6_15
Abstract: Mitochondria actively participate in oxygenic metabolism and are one of the major sources of reactive oxygen species (ROS) production in plant cells. However, instead of measuring ROS concentrations in organelles it is more worthwhile to… read more here.
Keywords: mitochondrial ros; production; ros; ros status ... See more keywords
Cellular and Molecular Processes in Pulmonary Hypertension.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-68748-9_2
Abstract: Pulmonary hypertension (PH) is a progressive lung disease characterized by persistent pulmonary vasoconstriction. Another well-recognized characteristic of PH is the muscularization of peripheral pulmonary arteries. This pulmonary vasoremodeling manifests in medial hypertrophy/hyperplasia of smooth muscle… read more here.
Keywords: pulmonary hypertension; ros; processes pulmonary; molecular processes ... See more keywords
Signal Function Studies of ROS, Especially RBOH-Dependent ROS, in Plant Growth, Development and Environmental Stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-019-09971-4
Abstract: Reactive oxygen species (ROS) are well known for their dual functions in plants. On the one hand, ROS were once thought to be harmful to plants because their excessive accumulation might lead to oxidative stress… read more here.
Keywords: plant growth; ros; plant; growth development ... See more keywords
ROS induced bactericidal activity of amorphous Zn-doped titanium oxide coatings and enhanced osseointegration in bacteria-infected rat tibias.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.02.036
Abstract: Titanium-based endosseous implants with high antibacterial and osseointegration activities are extremely required in clinics. To achieve this line, herein the doped coatings with three kinds of Zn doses were micro-arc oxidized (MAOed) on Ti. They… read more here.
Keywords: infected rat; ros; coatings enhanced; titanium ... See more keywords
The β2-adrenergic receptor-ROS signaling axis: an overlooked component of β2AR function?
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113690
Abstract: β2-adrenergic receptor (β2AR) agonists are clinically used to elicit rapid bronchodilation for the treatment of bronchospasms in pulmonary diseases such as asthma and COPD, both of which exhibit characteristically high levels of reactive oxygen species… read more here.
Keywords: axis; adrenergic receptor; ros; 2ar function ... See more keywords
Targeting antioxidant enzymes as a radiosensitizing strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.09.004
Abstract: Radiotherapy represents a major anti-cancer modality and effectively kills cancer cells through generation of reactive oxygen species (ROS). However, cancer cells are commonly characterized by increased activity of ROS-scavenging enzymes in adaptation to intrinsic oxidative… read more here.
Keywords: antioxidant enzymes; targeting antioxidant; ros; radiosensitizing strategy ... See more keywords
Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.005
Abstract: Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants, exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and neuroprotective activities. In the present study, we proved the deleterious effects of CA… read more here.
Keywords: hepatocellular carcinoma; hcc; mediated mitochondrial; ros ... See more keywords
Mitochondrial ROS overproduction impairs glutamatergic signaling in frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.207
Abstract: Glutamatergic neurotransmission is essential for learning and memory but an overactivation of the pathway may lead to calcium overload, excitotoxicity and neuronal death. Together with this, oxidative stress and mitochondrial dysfunction are all relevant to… read more here.
Keywords: mitochondrial ros; frontotemporal dementia; ros; ros overproduction ... See more keywords
Novel aspects of the activation of NADPH oxidase in neutrophils of rheumatic patients on biological therapy
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.02.015
Abstract: &NA; The relationship between inflammation and formation of reactive oxygen species (ROS) is still not completely understood and excessive inflammatory reaction is attributed to increased yet also to reduced ROS formation. To compare ROS formation… read more here.
Keywords: rheumatic patients; biological therapy; inflammation; ros ... See more keywords
STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101822
Abstract: Summary STAT3 is a transcription factor involved in several cellular activities including inflammation, proliferation, and survival, but it also plays a non-transcriptional role in modulating mitochondrial metabolism. Given its diverse functions in human cancers, it… read more here.
Keywords: inhibitor; opb 51602; stat3; ros ... See more keywords