2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.079
Abstract: Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum… read more here.
Keywords: sumoylation; accumulation; myeloid leukemia; ros accumulation ... See more keywords
New N-9- sulfonylpurine derivatives induce changes in mitochondrial function and ROS accumulation in carcinoma and leukemia cells in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.041
Abstract: Our recent studies showed significant antiproliferative capacity of newly synthesized N-9-sulfonylpyrimidine derivatives on human carcinoma, lymphoma, and leukemia cells. These derivatives behave as antimetabolites exploiting cellular metabolism to induce cytotoxicity in treated tumors’ cells [1-3].… read more here.
Keywords: sulfonylpurine; leukemia cells; ros accumulation; changes mitochondrial ... See more keywords
SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00484-6
Abstract: Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O2−) levels with increased accumulation of hydrogen peroxide (H2O2) in CLL cells vs.… read more here.
Keywords: cll; ros accumulation; accumulation cll; sirt3 overexpression ... See more keywords
Two Co(II) coordination polymers: treatment activity on myocardial injury during sepsis via reducing ROS accumulation in the cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2020.1823379
Abstract: Abstract Two coordination polymers on the basis of distinct nitrogen-donor ligands and biphenyl-2,2′,5,5′-tetracarboxylic acid H4(o,m-bpta), {[Co2(o,m-bpta)(1,3-bimb)2]·DMF·2H2O}n (1) {1,3-bimb = [1,3-phenylenebis(methylene)]bis(1H-imidazole)} and {[Co2(o,m-bpta)(1,4-bimb)2]·H2O}n (2) {1,4-bimb = [1,4-phenylenebis(methylene)]bis(1H-imidazole)} were prepared under solvothermal conditions. These two complexes were… read more here.
Keywords: coordination; ros accumulation; myocardial injury; two coordination ... See more keywords
JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/6726654
Abstract: It is an effective strategy to treat tuberculosis by enhancing reactive oxygen species- (ROS-) mediated killing of Mycobacterium tuberculosis in macrophages, but there are no current therapeutic agents targeting this pathway. Honeysuckle has been used… read more here.
Keywords: tuberculosis; jfd; ros accumulation; keap1 alkylation ... See more keywords
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0408
Abstract: Nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in rhabdomyosarcoma (RMS), and inactivation of NR4A1 (siNR4A1) or treatment with the NR4A1 antagonist 1,1-bis(3′-indoly)-1-(p-hydroxy-phenyl)methane (DIM-C-pPhOH) has antiproliferative and proapoptotic effects on RMS cells. However, the mechanism by… read more here.
Keywords: ros accumulation; accumulation il24; rms cells; il24 ... See more keywords
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1038802
Abstract: This study aimed to explore the protective roles of malvidin in life-threatened sepsis-associated encephalopathy (SAE) and illustrate the underlying mechanism. SAE mice models were developed and treated with malvidin for subsequently protective effects evaluation. Malvidin… read more here.
Keywords: sae; ros accumulation; mitochondrial dysfunction; sae mice ... See more keywords
Putrescine Depletion Affects Arabidopsis Root Meristem Size by Modulating Auxin and Cytokinin Signaling and ROS Accumulation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084094
Abstract: Polyamines (PAs) dramatically affect root architecture and development, mainly by unknown mechanisms; however, accumulating evidence points to hormone signaling and reactive oxygen species (ROS) as candidate mechanisms. To test this hypothesis, PA levels were modified… read more here.
Keywords: cytokinin signaling; ros accumulation; auxin cytokinin; size ... See more keywords