Curcumin induces concentration‐dependent alterations in mitochondrial function through ROS in C2C12 mouse myoblasts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27370
Abstract: Curcumin exhibits antioxidant properties in normal cells where the uptake is low, unlike in tumor cells where uptake is high and curcumin increases reactive oxygen species (ROS) production and cell death. Mitochondria are the main… read more here.
Keywords: mitochondrial function; ros levels; concentration; cell ... See more keywords
Profile of pterostilbene-induced redox homeostasis modulation in cardiac myoblasts and heart tissue
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9815-9
Abstract: This study was designed to investigate the effect of pterostilbene (PTS) on cardiac oxidative stress in vitro, as this is a simple and promising methodology to study cardiac disease. Cardiac myoblasts (H9c2 cells) and homogenised… read more here.
Keywords: cardiac tissue; pterostilbene; tissue; ros levels ... See more keywords
Dapagliflozin attenuates arrhythmic vulnerabilities by regulating connexin43 expression via the AMPK pathway in post-infarcted rat hearts.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114674
Abstract: We have demonstrated that dapagliflozin, a sodium-glucose cotransporter (SGLT) 2 inhibitor, attenuates reactive oxygen species (ROS) production. Connexin43 playing a role in ventricular arrhythmia is sensitive to redox status. No data are available on the… read more here.
Keywords: increased connexin43; ros levels; phosphorylation; significantly increased ... See more keywords
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112610
Abstract: Oxidative therapy, a strategy that specifically increases reactive oxygen species (ROS) levels in tumor cells by disrupting the redox homeostasis has gained increasing interest. The antitumor effects of the natural product piperlongumine (PL) appear to… read more here.
Keywords: design synthesis; apoptosis; breast cancer; ros levels ... See more keywords
80. Trans-resveratrol increases nitric oxide and heme-oxigenase-1 production and decreases ROS levels in endothelial cells incubated with plasma from preeclamptic patients
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.206
Abstract: Introduction Preeclampsia is characterized by hypertension and proteinuria at ⩾20 weeks of gestation and it is the leading cause of fetal-maternal morbidity and mortality worldwide. The pathophysiology of this syndrome is complex and involves several processes.… read more here.
Keywords: heme oxigenase; incubated plasma; preeclamptic patients; ros levels ... See more keywords
Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101835
Abstract: Reactive oxygen species (ROS) contribute to cellular redox environment and serve as signaling molecules. Excessive ROS can lead to oxidative stress that are involved in a broad spectrum of physiological and pathological conditions. Stem cells… read more here.
Keywords: ros; ros levels; stem cells; iscs ... See more keywords
Heterogeneity of ROS levels in antibiotic-exposed mycobacterial subpopulations confers differential susceptibility.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology"
DOI: 10.1099/mic.0.000797
Abstract: Phenotypically heterogeneous but genetically identical mycobacterial subpopulations exist in in vitro cultures, in vitro-infected macrophages, infected animal models and tuberculosis patients. In this regard, we recently reported the presence of two subpopulations of cells, which… read more here.
Keywords: susceptibility; differential susceptibility; mycobacterial subpopulations; antibiotic exposed ... See more keywords
Diphenyleneiodonium Treatment Inhibits the Development of Severe Herpes Stromal Keratitis Lesions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01014-22
Abstract: Neutrophils are one of the primary immune cell types involved in causing tissue damage after corneal HSV-1 infection. This study demonstrates that intracellular ROS production in the neutrophils in HSK lesions is not NOX2 dependent.… read more here.
Keywords: hsk lesions; intracellular ros; ros levels; severity ... See more keywords
MFN2 and BAG6 Synergistically Protect Against Cerebral Reperfusion Injury by Regulating ROS Levels and Autophagic Flux
Sign Up to like & getrecommendations! Published in 2025 at "Stroke"
DOI: 10.1161/strokeaha.125.052689
Abstract: BACKGROUND: MFN2 (mitofusin-2), a transmembrane dynamin-like protein located on the outer mitochondrial membrane, plays a key role in regulating mitochondrial fusion and autophagy. In vitro studies suggested that MFN2 may exert neuroprotective effects postischemia. In… read more here.
Keywords: ros levels; bag6; mfn2; reperfusion injury ... See more keywords
The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118827
Abstract: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ~1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Whilst advances… read more here.
Keywords: notch1 driven; figure; vulnerability notch1; ros levels ... See more keywords
Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication
Sign Up to like & getrecommendations! Published in 2025 at "Veterinary Research"
DOI: 10.1186/s13567-025-01595-9
Abstract: Increasing evidence has confirmed that oxidative stress plays a nonnegligible role in the viral pathogenic process. In this study, we investigated the role of reactive oxygen species (ROS) in the replication of pseudorabies virus (PRV).… read more here.
Keywords: ros; replication; pseudorabies virus; prv infection ... See more keywords