Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14669
Abstract: Human aldehyde oxidase (hAOX1) is a molybdoenzyme that oxidizes aldehydes and N-heterocyclic compounds, thereby generating hydrogen peroxide (H2 O2 ) and superoxide during turnover. hAOX1 has been shown previously to be inactivated under turnover conditions… read more here.
Keywords: aldehyde oxidase; insights ros; ros mediated; human aldehyde ... See more keywords
Antimicrobial effect of pimozide by targeting ROS-mediated killing in Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2465
Abstract: In spite of the higher nosocomial and community-acquired infections acquired by Staphylococcus aureus, emerging drug resistance is a leading cause of increased mortality and morbidity associated with the overuse of antimicrobials. It is an emergent… read more here.
Keywords: effect; pmz; effect pimozide; staphylococcus aureus ... See more keywords
Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2561-4
Abstract: Excessive production of reactive oxygen species (ROS), along with dysfunction of the antioxidant defense system, such as that involving superoxide dismutase (SOD), may play a major role in neuronal death following status epilepticus (SE). Neurosteroids,… read more here.
Keywords: death; neuronal death; ros mediated; status epilepticus ... See more keywords
Emamectin benzoate induces ROS-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.06.004
Abstract: Emamectin benzoate (EMB), a novel macrocyclic lactone insecticide, possesses high efficacy and beneficial selective toxicity in agriculture, but so far the EMB-induced cytotoxic action in arthropod insect remains unclear. The present studies were carried out… read more here.
Keywords: dna damage; ros mediated; apoptosis; mediated dna ... See more keywords
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.008
Abstract: Nicotinamide adenine dinucleotide (NAD) levels decrease with aging as a result of aging-associated CD38 upregulation. Here, we established a cell model with decreased cellular NAD levels by overexpressing CD38 or treating cells with FK866, an… read more here.
Keywords: degradation; mesenchymal transition; ros mediated; hydroxyprostaglandin dehydrogenase ... See more keywords
Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.02.017
Abstract: Physapubescin B, a steroidal compound extracted from the plant Physalis pubescens L. (Solanaceae), has been reported to possess anti-cancer potential, whereas the molecular mechanism remains elusive. In this study, we first demonstrated that physapubescin B… read more here.
Keywords: ros mediated; physapubescin; apoptotic cell; cell death ... See more keywords
Apigenin attenuates patulin‐induced apoptosis in HEK293 cells by modulating ROS‐mediated mitochondrial dysfunction and caspase signal pathway
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.07.018
Abstract: ABSTRACT Mycotoxins like patulin (PAT) are among the most significant food contaminant with regard to public health. This study aimed to evaluate the protective effect of apigenin (API), one of the most bioactive flavonoids in… read more here.
Keywords: patulin induced; ros mediated; apigenin; apoptosis hek293 ... See more keywords
ROS mediated apoptotic pathways in primary effusion lymphoma: Comment on induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic pathways in primary effusion lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101061
Abstract: Highlights • Mechanism of action of Shikonin against PEL.• Therapeutic potential of Shikonin as an alternative herbal medicine.• Interconnectivity among cellular stress, apoptosis pathways (extrinsic and intrinsic) and Shikonin. read more here.
Keywords: pathways primary; ros mediated; shikonin; primary effusion ... See more keywords
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101159
Abstract: Highlights • GILT is upregulated in chemoresistant LSC-enriched CD34+ progenitor cells.• Inhibition of GILT in AML cells sensitized them to Ara-C treatment through ROS-mediated mitochondrial damage and apoptosis.• PI3K/Akt/NRF2 pathway inhibition is critical for the… read more here.
Keywords: mitochondrial damage; mediated mitochondrial; ros mediated; targeting ifn ... See more keywords
Nobiletin triggers ROS-mediated pyroptosis through regulating autophagy in ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b07908
Abstract: Ovarian cancer is one of the most serious female malignancies worldwide. Despite intensive effort has been made to overcome ovarian cancer, there still remain limited optional treatments for this disease. Nobiletin, a prospective Food-derived phytochemical,… read more here.
Keywords: ros mediated; mediated pyroptosis; ovarian cancer; cancer cells ... See more keywords
Gold–Silver Bimetallic Nanoparticles Reduced with Herbal Leaf Extracts Induce ROS-Mediated Death in Both Promastigote and Amastigote Stages of Leishmania donovani
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02032
Abstract: Resistance to antileishmanial drugs such as sodium stibogluconate (SSG), amphotericin B (Amp-B), and miltefosine is on the rise, and alternate strategies for effective treatment have gained importance in recent years. Although nanoparticle (NP)-based composite drugs… read more here.
Keywords: ros mediated; bimetallic nanoparticles; silver bimetallic; leaf extracts ... See more keywords