ROS–NLRP3 signaling pathway induces sterile inflammation after thulium laser resection of the prostate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30663
Abstract: The sterile inflammation (SI) of the urinary tract is a common problem requiring serious consideration after prostatectomy. This study mainly focuses on the role of the reactive oxygen species–NLR family, pyrin domain‐containing 3 (ROS–NLRP3) signaling… read more here.
Keywords: ros nlrp3; sterile inflammation; signaling pathway; nlrp3 signaling ... See more keywords
ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108711
Abstract: Podocyte pyroptosis is an inflammatory form of cell death associated with Diabetic nephropathy (DN). It is reported that hyposialylated Angiopoietin-like-4 (Angptl4) secreted by glomerular podocytes plays an important role in the formation of proteinuria. Previous… read more here.
Keywords: mannac; ros nlrp3; injury; histopathology ... See more keywords
Mechanistic Insights into T-2 Toxin-Induced Thymic Epithelial Cell Injury and Immunotoxicity via the ROS-NF-κB-NLRP3 Signaling Axis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c00355
Abstract: Thymic epithelial cells (TECs) are critical for thymic structure and function, yet the impact of T-2 toxin (T-2) on TECs and related molecular pathways remains unclear. This study sheds light on the mechanisms of T-2-induced… read more here.
Keywords: induced thymic; signaling axis; thymic epithelial; injury ... See more keywords
BMSC Alleviates Dry Eye by Inhibiting the ROS-NLRP3-IL-1β Signaling Axis by Reducing Inflammation Levels
Sign Up to like & getrecommendations! Published in 2024 at "Current Eye Research"
DOI: 10.1080/02713683.2024.2324434
Abstract: Abstract Purpose Bone marrow mesenchymal stem cells (BMSC) have multiple biological functions and are widely involved in regulating inflammatory diseases, tissue repair and regeneration. However, the mechanism of their action in dry eye disease (DED)… read more here.
Keywords: dry eye; inhibiting ros; signaling axis; nlrp3 signaling ... See more keywords
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2032021
Abstract: Abstract Pyroptosis is an exceptional mode of inflammation and programmed cell death involved in inflammasomes and Caspase-1 activation and inflammatory cytokines releasing. Our goal is to explore whether uranium (U)-intoxication could induce NRK-52E cells pyroptosis… read more here.
Keywords: nlrp3 caspase; ros nlrp3; pyroptosis; nrk 52e ... See more keywords
T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjaf039
Abstract: Kawasaki disease (KD) is an acute febrile systemic vasculitis associated with the development of coronary artery lesion and coronary artery aneurysm. This condition is characterized by sustained vascular inflammation and endothelial dysfunction, in which pyroptosis… read more here.
Keywords: pyroptosis; kawasaki disease; sod2 ros; endothelial cells ... See more keywords
Norcantharidin ameliorates estrogen deficient-mediated bone loss by attenuating the activation of extracellular signal-regulated kinase/ROS/NLRP3 inflammasome signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1019478
Abstract: Osteoporosis, characterized by reduced bone mass, aberrant bone architecture, and elevated bone fragility, is driven by a disruption of bone homeostasis between bone resorption and bone formation. However, up to now, no drugs are perfect… read more here.
Keywords: ameliorates estrogen; bone; ros nlrp3; bone loss ... See more keywords
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122315
Abstract: Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. Notedly, the ROS (reactive oxygen species) level in macrophages is intimately implicated in macrophage M1… read more here.
Keywords: macrophage polarization; ros nlrp3; progression; trpv4 ... See more keywords
Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12050999
Abstract: Cerebral ischemia/reperfusion causes exacerbated neuronal damage involving excessive neuroinflammation and oxidative stress. ROS is considered a signal molecule to activate NLRP3; thus, the ROS/NLRP3/pyroptosis axis plays a vital role in the pathogenesis of cerebral ischemia/reperfusion… read more here.
Keywords: ros nlrp3; pyroptosis; cerebral ischemia; ischemia reperfusion ... See more keywords