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   Articles with "ros p38" as a keyword



Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c09146

Abstract: Hyperuricemia (HUA) is a prevalent metabolic disorder, with limited therapeutic options. This study investigated the effects and mechanisms of urolithin C (UroC), a gut-microbiota-derived bioactive metabolite from ellagitannin-rich foods, in the management of HUA. In… read more here.

Keywords: mapk axis; ros p38; erk mapk; hua ... See more keywords

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc05278d

Abstract: Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic… read more here.

Keywords: ros p38; glutathione transferases; activate ros; transferases activate ... See more keywords

Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma

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recommendations! Published in 2017 at "BMC Neurology"

DOI: 10.1186/s12883-017-0843-0

Abstract: BackgroundJuglone is a natural pigment, which has cytotoxic effect against various human tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells (TSCs) has not been demonstrated.MethodsTSCs of glioma were enriched from… read more here.

Keywords: ros p38; like cells; juglone; tumor stem ... See more keywords

Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12040838

Abstract: Vascular aging is an important factor contributing to cardiovascular diseases, such as hypertension and atherosclerosis. Hyperlipidemia or fatty accumulation may play an important role in vascular aging and cardiovascular diseases. Canagliflozin (CAN), a sodium-glucose cotransporter… read more here.

Keywords: p38 jnk; ros p38; jnk pathway; induced palmitic ... See more keywords

SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways

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recommendations! Published in 2022 at "Immune Network"

DOI: 10.4110/in.2022.22.e33

Abstract: Suppressors of cytokine signaling (SOCS) have emerged as potential regulators of macrophage function. We have investigated mechanisms of SOCS3 action on type 2 macrophage (M2) differentiation induced by glucocorticoid using human monocytic cell lines and… read more here.

Keywords: ros p38; gilz; p38 mapk; regulation ... See more keywords