Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05278d
Abstract: Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic… read more here.
Keywords: ros p38; glutathione transferases; activate ros; transferases activate ... See more keywords
Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma
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DOI: 10.1186/s12883-017-0843-0
Abstract: BackgroundJuglone is a natural pigment, which has cytotoxic effect against various human tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells (TSCs) has not been demonstrated.MethodsTSCs of glioma were enriched from… read more here.
Keywords: ros p38; like cells; juglone; tumor stem ... See more keywords
Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway
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DOI: 10.3390/antiox12040838
Abstract: Vascular aging is an important factor contributing to cardiovascular diseases, such as hypertension and atherosclerosis. Hyperlipidemia or fatty accumulation may play an important role in vascular aging and cardiovascular diseases. Canagliflozin (CAN), a sodium-glucose cotransporter… read more here.
Keywords: p38 jnk; ros p38; jnk pathway; induced palmitic ... See more keywords
SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Immune Network"
DOI: 10.4110/in.2022.22.e33
Abstract: Suppressors of cytokine signaling (SOCS) have emerged as potential regulators of macrophage function. We have investigated mechanisms of SOCS3 action on type 2 macrophage (M2) differentiation induced by glucocorticoid using human monocytic cell lines and… read more here.
Keywords: ros p38; gilz; p38 mapk; regulation ... See more keywords