ROS-Responsive Blended Nanoparticles: Cascade-Amplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900720
Abstract: Sonodynamic therapy (SDT) not only has greater tissue-penetrating depth compared to photo-stimulated therapies, but also can also trigger rapid drug release to achieve synergistic sonochemotherapy. Here, reactive oxygen species (ROS)-responsive IR780/PTL- nanoparticles (NPs) are designed… read more here.
Keywords: drug release; sdt; ir780 ptl; ros responsive ... See more keywords
Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202300028
Abstract: Nitinol (NiTi) alloy is an ideal material for preparing neurointerventional stents due to its excellent mechanical properties and biocompatibility. However, NiTi stents without surface‐specific functionalization cause a high rate of stent thrombosis and in‐stent restenosis… read more here.
Keywords: exosome coating; responsive exosome; niti alloy; ros responsive ... See more keywords
Reactive Oxygen Species Responsive Cleavable Hierarchical Metallic Supra-Nanostructure.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202202694
Abstract: A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported. HMSN structured with thin branches composed of primary gold (Au) nanocrystals and silver (Ag) nano-linkers is synthesized by a one-pot aqueous synthesis… read more here.
Keywords: reactive oxygen; hmsn; cleavable hierarchical; oxygen species ... See more keywords
Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.023
Abstract: Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest in recent years. On the one hand, a high ROS level has been detected in many types of tumor cells. On the other hand, ROS generation… read more here.
Keywords: reactive oxygen; sensitive polymeric; oxygen species; polymeric nanocarriers ... See more keywords
Chitosan derivatives functionalized dual ROS-responsive nanocarriers to enhance synergistic oxidation-chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.119087
Abstract: The efficient triggering of prodrug release has become a challengeable task for stimuli-responsive nanomedicine utilized in cancer therapy due to the subtle differences between normal and tumor tissues and heterogeneity. In this work, a dual… read more here.
Keywords: ros responsive; dual ros; oxidation chemotherapy; synergistic oxidation ... See more keywords
Nano mesoporous silica for cancer treatment: ROS-responsive and redox-responsive carriers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101510
Abstract: Abstract Reactive oxygen species ROS and redox agents are two features of cancer medium, which could be used through responsive drug delivery systems for cancer treatment. Furthermore, mesoporous silica nanoparticles (MSNs) have special characteristics to… read more here.
Keywords: redox responsive; responsive redox; drug; responsive carriers ... See more keywords
Recent Advances on Reactive Oxygen Species (ROS)-Responsive Delivery and Diagnosis System.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00628
Abstract: Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By… read more here.
Keywords: reactive oxygen; oxygen species; species ros; delivery ... See more keywords
Reactive oxygen species (ROS)-responsive polymersomes with site-specific chemotherapeutic delivery into tumors via spacer design chemistry.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b01748
Abstract: The lack of cellular and tissue specificity in conventional chemotherapies along with the generation of a complex tumor microenvironment (TME) limit the dosage of active agents that reaches tumor sites thereby resulting in ineffective responses… read more here.
Keywords: spacer chemistry; chemistry; pss; ros responsive ... See more keywords
ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03227
Abstract: Despite the promising benefits of immune checkpoint inhibitors (ICIs) in clinical cancer treatments, the therapeutic efficacy is largely restricted by low antitumor immunity and limited intratumor delivery in solid tumors. Herein, we designed a reactive… read more here.
Keywords: apd cabazitaxel; ros responsive; antitumor immunity; intratumor delivery ... See more keywords
ROS-Responsive Nanoparticle Delivery of mRNA and Photosensitizer for Combinatorial Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03784
Abstract: Messenger RNA (mRNA) therapy has shown tremendous potential for different diseases including cancer. While mRNA has been extensively used in cancer vaccine development as antigen or in cancer immunotherapy as immunomodulatory agent, the combination of… read more here.
Keywords: nanoparticle; therapy; ros responsive; cancer ... See more keywords
Physical- and Chemical-Dually ROS-Responsive Nano-in-Gel Platforms with Sequential Release of OX40 Agonist and PD-1 Inhibitor for Augmented Combination Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04767
Abstract: Combination immunotherapy synergizing the PD-1 blockade with OX40 agonism has become a research hotspot, due to its enormous potential to overcome the restricted clinical objective response suffered by monotherapy. Questions of timing and sequence have… read more here.
Keywords: dually ros; combination immunotherapy; chemical dually; combination ... See more keywords