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Published in 2022 at "Small"
DOI: 10.1002/smll.202203823
Abstract: Although small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severely limits its extensive clinical applications due to uncontrolled siRNA biodistribution. Herein, a spatially controlled siRNA activation strategy is…
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Keywords:
unprotonatable ros;
therapy synergistic;
ros sensitive;
therapy ... See more keywords
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Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115787
Abstract: Although the clinical usage of drugs administration was raising, the application of nanoparticles encapsulating the hydrophobic drugs with plummy efficiency was very scarce for atherosclerosis (AS) treatment. In this work, a novel dual ROS-sensitive and…
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Keywords:
hasf cur;
dual ros;
cur micelles;
cur ... See more keywords
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Published in 2018 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.7b04751
Abstract: Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize remotely controlled drug release by light-activated…
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Keywords:
remotely controlled;
drug;
size;
dox ... See more keywords
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Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2086944
Abstract: Abstract Oxidative stress due to excessive reactive oxygen species (ROS) production in the skin microenvironment is one of the main mechanisms in psoriasis pathogenesis. A nano drug delivery system based on ROS-responsive release can enhance…
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Keywords:
mpeg;
ros sensitive;
methoxypolyethylene glycol;
drug ... See more keywords
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Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s208938
Abstract: Background Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, trigger biodegradation of polymer-based nanoparticles (NPs) bearing pinacol-type boronic ester groups. These NPs may selectively release their cargo, in this case paclitaxel (PTX), at…
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Keywords:
anti tumor;
efficacy;
sensitive nps;
ptx ... See more keywords
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Published in 2022 at "Diabetes"
DOI: 10.2337/db21-1079
Abstract: Excessive production of renal reactive oxygen species (ROS) play a major role in diabetic kidney disease (DKD). Here, we provide key novel findings demonstrating the predominant pathological role of the prooxidant enzyme NADPH oxidase-NOX5 in…
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Keywords:
nox5;
inflammation;
ros sensitive;
ros formation ... See more keywords
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Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.608150
Abstract: Objective: Osteoarthritis (OA) is a common subtype of arthritis. To date, treatment of OA focuses primarily on alleviating pain and improving joint function. The lack of a vascular system within synovial joints and the rapid…
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Keywords:
treatment;
osteoarthritis;
inflammation;
chondrogenic differentiation ... See more keywords
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Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1168192
Abstract: Background: Recently, various combination therapies for tumors have garnered popularity because of their synergistic effects in improving therapeutic efficacy and reducing side effects. However, incomplete intracellular drug release and a single method of combining drugs…
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Keywords:
ros sensitive;
ce6 ptp;
therapy;
drug release ... See more keywords