Abstract A08: Fast and efficient generation of conditional ROSA26-based mouse models that recapitulate oncogene activation in T-cell acute lymphoblastic leukemia
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DOI: 10.1158/1538-7445.mousemodels17-a08
Abstract: T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive hematologic tumors that result from the malignant transformation of T-cell progenitors. Due to intensified chemotherapy, the prognosis of T-ALL has gradually improved. Nevertheless, this clinical improvement is most… read more here.
Keywords: mouse models; cell acute; rosa26; biology ... See more keywords
Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model
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DOI: 10.4254/wjh.v10.i2.277
Abstract: AIM To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (Fah-/-) mice by homologous-recombination-mediated targeted addition of the Fah gene. METHODS C57BL/6 Fah∆exon5 mice served as an animal model for human tyrosinaemia type 1… read more here.
Keywords: fah; rosa26; fah gene; mice ... See more keywords