Web‐accessible molecular modeling with Rosetta: The Rosetta Online Server that Includes Everyone (ROSIE)
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3313
Abstract: The Rosetta molecular modeling software package provides a large number of experimentally validated tools for modeling and designing proteins, nucleic acids, and other biopolymers, with new protocols being added continually. While freely available to academic… read more here.
Keywords: molecular modeling; rosetta protocols; rosetta; server ... See more keywords
The morphological, elastic, and electric properties of dust aggregates in comets: A close look at COSIMA/Rosetta’s data on dust in comet 67P/Churyumov-Gerasimenko
Sign Up to like & getrecommendations! Published in 2020 at "Planetary and Space Science"
DOI: 10.1016/j.pss.2019.104825
Abstract: Abstract The Cometary Secondary Ion Mass Analyzer (COSIMA) onboard ESA’s Rosetta orbiter has revealed that dust particles in the coma of comet 67P/Churyumov-Gerasimenko are aggregates of small grains. We study the morphological, elastic, and electric… read more here.
Keywords: chemistry; dust aggregates; comet 67p; dust ... See more keywords
Accurate Prediction of Enzyme Thermostabilization with Rosetta Using AlphaFold Ensembles
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01083
Abstract: Thermostability enhancement is a fundamental aspect of protein engineering as a biocatalyst’s half-life is key for its industrial and biotechnological application, particularly at high temperatures and under harsh conditions. Thermostability changes upon mutation originate from… read more here.
Keywords: accurate prediction; rosetta; using alphafold; prediction ... See more keywords
Protocols for Requirement-Driven Protein Design in the Rosetta Modeling Program
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00060
Abstract: We have developed a set of protocols in the molecular modeling program Rosetta for performing requirement-driven protein design. First, the user specifies a set of structural features that need to be present in the designed… read more here.
Keywords: protein; driven protein; modeling program; requirement driven ... See more keywords
Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85259-6
Abstract: Horizontal gene transfer (HGT), the movement of heritable materials between distantly related organisms, is crucial in eukaryotic evolution. However, the scale of HGT in choanoflagellates, the closest unicellular relatives of metazoans, and its possible roles… read more here.
Keywords: choanoflagellate salpingoeca; salpingoeca rosetta; rosetta; gene transfer ... See more keywords
Plasma source and loss at comet 67P during the Rosetta mission
Sign Up to like & getrecommendations! Published in 2018 at "Astronomy and Astrophysics"
DOI: 10.1051/0004-6361/201832881
Abstract: Context. The Rosetta spacecraft provided us with a unique opportunity to study comet 67P/Churyumov-Gerasimenko from a close perspective and over a two-year time period. Comet 67P is a weakly active comet. It was therefore unexpected… read more here.
Keywords: rosetta mission; source; comet 67p; ion ... See more keywords
Evolution of the ion environment of comet 67P during the Rosetta mission as seen by RPC-ICA
Sign Up to like & getrecommendations! Published in 2017 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stx1491
Abstract: Rosetta has followed comet 67P from low activity at more than 3.6 au heliocentric distance to high activity at perihelion (1.24 au) and then out again. We provide a general overview of the evolutio ... read more here.
Keywords: ion environment; 67p rosetta; evolution ion; comet 67p ... See more keywords
Rosetta:MSF: a modular framework for multi-state computational protein design
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005600
Abstract: Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties. Rosetta is a software suite including algorithms for computational modeling and analysis of protein… read more here.
Keywords: state; protein; multi state; rosetta ... See more keywords
Rosetta design with co-evolutionary information retains protein function
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008568
Abstract: Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been tailored to address various protein… read more here.
Keywords: rosetta design; protein function; biology; rosetta ... See more keywords
PlaceWaters: Real-time, explicit interface water sampling during Rosetta ligand docking
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269072
Abstract: Water molecules at the protein-small molecule interface often form hydrogen bonds with both the small molecule ligand and the protein, affecting the structural integrity and energetics of a binding event. The inclusion of these ‘bridging… read more here.
Keywords: explicit interface; ligand docking; water; rosetta ... See more keywords
Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44060174
Abstract: The global spread of multi- and pan-resistant bacteria has triggered research to identify novel strategies to fight these pathogens, such as antimicrobial peptides and, more recently, bacteriophages. In a proof-of-concept study, we have genetically modified… read more here.
Keywords: t7select phage; apidaecin; api802 api806; coli rosetta ... See more keywords