Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus
Sign Up to like & getrecommendations! Published in 2018 at "Protoplasma"
DOI: 10.1007/s00709-018-1233-1
Abstract: Terpenoid indole alkaloid (TIA) biosynthetic pathway of Catharanthus roseus possesses the major attention in current metabolic engineering efforts being the sole source of highly expensive antineoplastic molecules vinblastine and vincristine. The entire TIA pathway is… read more here.
Keywords: biosynthesis; tia; pathway; roseus ... See more keywords
Endophytic consortium with growth-promoting and alkaloid enhancing capabilities enhance key terpenoid indole alkaloids of Catharanthus roseus in the winter and summer seasons
Sign Up to like & getrecommendations! Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2021.113437
Abstract: Abstract Catharanthus roseus produces medicinally important terpenoid indole alkaloids (TIAs) such as vindoline, vinblastine, and vincristine, but in very small amounts. The various microbial consortium consisting of plant growth-promoting and alkaloid enhancing endophytes were developed… read more here.
Keywords: consortium; content yield; summer; roseus ... See more keywords
Metabolomics Analysis Reveals that Ethylene and Methyl Jasmonate Regulate Different Branch Pathways to Promote the Accumulation of Terpenoid Indole Alkaloids in Catharanthus roseus.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.7b00782
Abstract: The medicinal plant Catharanthus roseus accumulates large numbers of terpenoid indole alkaloids (TIAs), including the pharmaceutically important vinblastine, vincristine, ajmalicine, and serpentine. The phytohormone ethylene or methyl jasmonate (MeJA) can markedly enhance alkaloid accumulation. The… read more here.
Keywords: catharanthus roseus; analysis; tia biosynthesis; roseus ... See more keywords
Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation
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DOI: 10.3390/md20030188
Abstract: Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities. Chitooligosaccharides are the only… read more here.
Keywords: vindoline catharanthine; catharanthus roseus; expression levels; antioxidant enzymes ... See more keywords
Ethyl Methane Sulfonate and Sodium Azide-Mediated Chemical and X-ray-Mediated Physical Mutagenesis Positively Regulate Peroxidase 1 Gene Activity and Biosynthesis of Antineoplastic Vinblastine in Catharanthus roseus
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11212885
Abstract: Catharanthus roseus synthesizes bioactive therapeutic metabolites, known as monoterpenoid indole alkaloids (MIAs), including antineoplastic vinblastine and vincristine, which have high global demand, and antihypertensive ajmalicine, a serpentine. However, the in planta biosynthesis and accumulation of… read more here.
Keywords: biosynthesis; sodium azide; mutagenesis; roseus ... See more keywords
Salt tolerance during the seedling production stage of Catharanthus roseus, Tagetes patula and Celosia argentea
Sign Up to like & getrecommendations! Published in 2020 at "Revista Ciencia Agronomica"
DOI: 10.5935/1806-6690.20200059
Abstract: The guarantee of water supply for irrigated agriculture in the semi-arid region must necessarily involve the use of lower quality water, such as brackish water. The objective of the present work was to evaluate the… read more here.
Keywords: seedling production; tolerance; argentea; roseus ... See more keywords