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   Articles with "rosuvastatin" as a keyword



Cerivastatin for lowering lipids.

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recommendations! Published in 2017 at "Cochrane Database of Systematic Reviews"

DOI: 10.1002/14651858.cd012501

Abstract: BACKGROUND: Cerivastatin was the most potent statin until it was withdrawn from the market due to a number of fatalities due to rhabdomyolysis, however, the dose-related magnitude of effect of cerivastatin on blood lipids is… read more here.

Keywords: ldl cholesterol; rosuvastatin; cholesterol; cerivastatin ... See more keywords

Ezetimibe in high-risk, previously treated statin patients: a systematic review and network meta-analysis of lipid efficacy

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recommendations! Published in 2018 at "Clinical Research in Cardiology"

DOI: 10.1007/s00392-018-1379-z

Abstract: PurposeWhile statins are used as first-line treatments for high-risk patients with hypercholesterolemia, statin monotherapy is often insufficient to achieve target low-density lipoprotein cholesterol (LDL-C) levels. Second-line treatment options include up-titration of statin dose, switching to… read more here.

Keywords: risk; rosuvastatin; high risk; treated statin ... See more keywords

Rosuvastatin Attenuates High-Salt and Cholesterol Diet Induced Neuroinflammation and Cognitive Impairment via Preventing Nuclear Factor KappaB Pathway

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recommendations! Published in 2017 at "Neurochemical Research"

DOI: 10.1007/s11064-017-2264-2

Abstract: Recent attention is focused on the impact of diet on health and mental well-being. High-salt and cholesterol diet (HSCD) is known to be associated with neuroinflammation which is the predominant factor for neurodegenerative disease like… read more here.

Keywords: hscd; rosuvastatin; cognitive impairment; factor ... See more keywords

Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects

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recommendations! Published in 2017 at "Advances in Therapy"

DOI: 10.1007/s12325-017-0601-0

Abstract: IntroductionObeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and… read more here.

Keywords: dextromethorphan; digoxin; rosuvastatin; warfarin ... See more keywords

Pharmacokinetic Interaction Between Telmisartan and Rosuvastatin/Ezetimibe After Multiple Oral Administration in Healthy Subjects

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recommendations! Published in 2020 at "Advances in Therapy"

DOI: 10.1007/s12325-020-01592-8

Abstract: Telmisartan, rosuvastatin and ezetimibe are commonly recommended as combination therapies. However, the pharmacokinetic (PK) interaction among these therapeutic drugs has not been clearly reported. The objective of this study was to investigate possible interactions between… read more here.

Keywords: pharmacokinetic interaction; rosuvastatin ezetimibe; telmisartan rosuvastatin; rosuvastatin ... See more keywords

Effect of rosuvastatin on sortilin and fetuin-A in type 2 diabetic patients: a randomized controlled trial

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recommendations! Published in 2024 at "International Journal of Diabetes in Developing Countries"

DOI: 10.1007/s13410-024-01324-6

Abstract: Rosuvastatin is a drug used for decreasing the risk of cardiovascular complications in type 2 diabetes mellitus (T2DM) patients. It is hypothesized that fetuin-A encourages lipid-induced insulin resistance and sortilin may increase the risk of… read more here.

Keywords: sortilin fetuin; placebo; rosuvastatin; t2dm patients ... See more keywords
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Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia

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recommendations! Published in 2020 at "American Journal of Cardiovascular Drugs"

DOI: 10.1007/s40256-020-00421-1

Abstract: Rosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA reductase inhibitor (i.e. statin) with particularly strong inhibitory effects on hepatic cholesterol synthesis, and ezetimibe, which inhibits the intestinal absorption of cholesterol. A fixed-dose combination (FDC) of… read more here.

Keywords: rosuvastatin ezetimibe; rosuvastatin; hypercholesterolemia; cholesterol ... See more keywords
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Pharmacokinetics of Rosuvastatin: A Systematic Review of Randomised Controlled Trials in Healthy Adults

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recommendations! Published in 2021 at "Clinical Pharmacokinetics"

DOI: 10.1007/s40262-020-00978-9

Abstract: Background Rosuvastatin is a lipid-lowering drug that works by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme responsible for producing cholesterol in humans. The pharmacokinetic data of rosuvastatin are considerably variable across studies. Objective To… read more here.

Keywords: randomised controlled; healthy adults; pharmacokinetics rosuvastatin; rosuvastatin ... See more keywords

Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin.

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recommendations! Published in 2017 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2016.12.019

Abstract: BACKGROUND AND AIMS High plasma LDL-cholesterol (LDL-C) and platelet responses have major pathogenic roles in atherothrombosis. Thus, statins and anti-platelet drugs constitute mainstays in cardiovascular prevention/treatment. However, the role of platelet tissue factor-dependent procoagulant activity… read more here.

Keywords: rosuvastatin; cholesterol; pca; membrane cholesterol ... See more keywords

Comparison of Pharmacokinetics and Safety of a Fixed-dose Combination of Rosuvastatin and Ezetimibe Versus Separate Tablets in Healthy Subjects.

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recommendations! Published in 2017 at "Clinical therapeutics"

DOI: 10.1016/j.clinthera.2017.07.038

Abstract: PURPOSE Rosuvastatin and ezetimibe are concomitantly used for dyslipidemia treatment. Compared with separate tablets, fixed-dose combination (FDC) tablets of rosuvastatin/ezetimibe could increase patient compliance. The aim of this study was to compare the pharmacokinetic (PK)… read more here.

Keywords: rosuvastatin ezetimibe; dose combination; rosuvastatin; study ... See more keywords

Rosuvastatin suppresses cytokine production and lung inflammation in asthmatic, hyperlipidemic and asthmatic-hyperlipidemic rat models.

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recommendations! Published in 2020 at "Cytokine"

DOI: 10.1016/j.cyto.2020.154993

Abstract: BACKGROUND Given the role that T lymphocytes play on the pathogenesis of allergic asthma, drugs targeting Th2 and Th17 cells may be a hopeful therapeutic strategy. This study aimed to evaluate the effect of rosuvastatin… read more here.

Keywords: rosuvastatin; asthmatic hyperlipidemic; lung inflammation; cytokine production ... See more keywords