Cerivastatin for lowering lipids.
Sign Up to like & getrecommendations! Published in 2017 at "Cochrane Database of Systematic Reviews"
DOI: 10.1002/14651858.cd012501
Abstract: BACKGROUND: Cerivastatin was the most potent statin until it was withdrawn from the market due to a number of fatalities due to rhabdomyolysis, however, the dose-related magnitude of effect of cerivastatin on blood lipids is… read more here.
Keywords: ldl cholesterol; rosuvastatin; cholesterol; cerivastatin ... See more keywords
Ezetimibe in high-risk, previously treated statin patients: a systematic review and network meta-analysis of lipid efficacy
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DOI: 10.1007/s00392-018-1379-z
Abstract: PurposeWhile statins are used as first-line treatments for high-risk patients with hypercholesterolemia, statin monotherapy is often insufficient to achieve target low-density lipoprotein cholesterol (LDL-C) levels. Second-line treatment options include up-titration of statin dose, switching to… read more here.
Keywords: risk; rosuvastatin; high risk; treated statin ... See more keywords
Rosuvastatin Attenuates High-Salt and Cholesterol Diet Induced Neuroinflammation and Cognitive Impairment via Preventing Nuclear Factor KappaB Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2264-2
Abstract: Recent attention is focused on the impact of diet on health and mental well-being. High-salt and cholesterol diet (HSCD) is known to be associated with neuroinflammation which is the predominant factor for neurodegenerative disease like… read more here.
Keywords: hscd; rosuvastatin; cognitive impairment; factor ... See more keywords
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects
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DOI: 10.1007/s12325-017-0601-0
Abstract: IntroductionObeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and… read more here.
Keywords: dextromethorphan; digoxin; rosuvastatin; warfarin ... See more keywords
Pharmacokinetic Interaction Between Telmisartan and Rosuvastatin/Ezetimibe After Multiple Oral Administration in Healthy Subjects
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DOI: 10.1007/s12325-020-01592-8
Abstract: Telmisartan, rosuvastatin and ezetimibe are commonly recommended as combination therapies. However, the pharmacokinetic (PK) interaction among these therapeutic drugs has not been clearly reported. The objective of this study was to investigate possible interactions between… read more here.
Keywords: pharmacokinetic interaction; rosuvastatin ezetimibe; telmisartan rosuvastatin; rosuvastatin ... See more keywords
Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia
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DOI: 10.1007/s40256-020-00421-1
Abstract: Rosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA reductase inhibitor (i.e. statin) with particularly strong inhibitory effects on hepatic cholesterol synthesis, and ezetimibe, which inhibits the intestinal absorption of cholesterol. A fixed-dose combination (FDC) of… read more here.
Keywords: rosuvastatin ezetimibe; rosuvastatin; hypercholesterolemia; cholesterol ... See more keywords
Pharmacokinetics of Rosuvastatin: A Systematic Review of Randomised Controlled Trials in Healthy Adults
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DOI: 10.1007/s40262-020-00978-9
Abstract: Background Rosuvastatin is a lipid-lowering drug that works by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme responsible for producing cholesterol in humans. The pharmacokinetic data of rosuvastatin are considerably variable across studies. Objective To… read more here.
Keywords: randomised controlled; healthy adults; pharmacokinetics rosuvastatin; rosuvastatin ... See more keywords
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2016.12.019
Abstract: BACKGROUND AND AIMS High plasma LDL-cholesterol (LDL-C) and platelet responses have major pathogenic roles in atherothrombosis. Thus, statins and anti-platelet drugs constitute mainstays in cardiovascular prevention/treatment. However, the role of platelet tissue factor-dependent procoagulant activity… read more here.
Keywords: rosuvastatin; cholesterol; pca; membrane cholesterol ... See more keywords
Comparison of Pharmacokinetics and Safety of a Fixed-dose Combination of Rosuvastatin and Ezetimibe Versus Separate Tablets in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.07.038
Abstract: PURPOSE Rosuvastatin and ezetimibe are concomitantly used for dyslipidemia treatment. Compared with separate tablets, fixed-dose combination (FDC) tablets of rosuvastatin/ezetimibe could increase patient compliance. The aim of this study was to compare the pharmacokinetic (PK)… read more here.
Keywords: rosuvastatin ezetimibe; dose combination; rosuvastatin; study ... See more keywords
Rosuvastatin suppresses cytokine production and lung inflammation in asthmatic, hyperlipidemic and asthmatic-hyperlipidemic rat models.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.154993
Abstract: BACKGROUND Given the role that T lymphocytes play on the pathogenesis of allergic asthma, drugs targeting Th2 and Th17 cells may be a hopeful therapeutic strategy. This study aimed to evaluate the effect of rosuvastatin… read more here.
Keywords: rosuvastatin; asthmatic hyperlipidemic; lung inflammation; cytokine production ... See more keywords
Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173260
Abstract: Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor,… read more here.
Keywords: recovery; rosuvastatin; injury; nerve ... See more keywords