Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Progress"
DOI: 10.1002/btpr.2966
Abstract: To meet the challenges of global health, vaccine design and development must be reconsidered to achieve cost of goods as low as 15¢ per dose. A new recombinant protein‐based rotavirus vaccine candidate derived from non‐replicative… read more here.
Keywords: product; fermentation; rotavirus vaccine; process ... See more keywords
Rotavirus epidemiology and vaccine demand: considering Bangladesh chapter through the book of global disease burden
Sign Up to like & getrecommendations! Published in 2017 at "Infection"
DOI: 10.1007/s15010-017-1082-4
Abstract: BackgroundRotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged read more here.
Keywords: rotavirus vaccine; rotavirus; disease burden; epidemiology ... See more keywords
Epidemiology of intussusception among children less than 2 years of age; findings from baseline surveillance before rotavirus vaccine introduction in Myanmar
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06601
Abstract: Background Rotavirus vaccine was planned to be introduced in the National Immunization Program of Myanmar in 2020. Reported potential association of a small increased risk of intussusception after rotavirus vaccination in some countries is a… read more here.
Keywords: intussusception; age; rotavirus vaccine; epidemiology ... See more keywords
Stability of heat stable, live attenuated Rotavirus vaccine (ROTASIIL®).
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.04.025
Abstract: Vaccines currently available across the globe are stored and transported in a continuous cold-chain at 2-8°C or below -20°C. A temperature excursion outside this range affects the potency of the vaccines. Such vaccines need to… read more here.
Keywords: rotavirus vaccine; vaccine; vaccine rotasiil; temperature ... See more keywords
Early impact of rotavirus vaccine in under 5year old children hospitalized due to diarrhea, Swaziland.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.07.072
Abstract: BACKGROUND Swaziland introduced rotavirus vaccine in the National Immunization Program, in May 2015, with the objective of reducing the burden of rotavirus diarrheal disease. We monitored the early impact of the vaccine in reducing rotavirus… read more here.
Keywords: rotavirus vaccine; rotavirus; diarrhea; vaccine ... See more keywords
Impact and effectiveness of pentavalent rotavirus vaccine in children
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.12.056
Abstract: BACKGROUND Burkina Faso was one of the first African nations to introduce pentavalent rotavirus vaccine (RV5, RotaTeq) into its national immunization program in October 2013. We describe the impact and effectiveness of rotavirus vaccine on… read more here.
Keywords: burkina faso; pentavalent rotavirus; age; rotavirus vaccine ... See more keywords
Distribution of rotavirus genotypes associated with acute diarrhoea in Zimbabwean children less than five years old before and after rotavirus vaccine introduction.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.03.069
Abstract: BACKGROUND Sentinel surveillance for diarrhoea is important to monitor changes in rotavirus epidemiological trends and circulating genotypes among children under 5 years before and after vaccine introduction. The Zimbabwe Ministry of Health and Child Care introduced… read more here.
Keywords: rotavirus vaccine; rotavirus; vaccine introduction; diarrhoea ... See more keywords
Impact of rotavirus vaccine introduction and genotypic characteristics of rotavirus strains in children less than 5 years of age with gastroenteritis in Ethiopia: 2011-2016.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.09.048
Abstract: INTRODUCTION A monovalent rotavirus vaccine was introduced in the Ethiopian Expanded Program on Immunization from November 2013. We compared impact of rotavirus vaccine introduction on rotavirus associated acute diarrhea hospitalizations and genotypic characteristics of rotavirus… read more here.
Keywords: introduction; age; rotavirus vaccine; rotavirus ... See more keywords
Budget Impact Analysis of Rotavirus Vaccine Adoption in the Childhood Immunization Schedule of Iran.
Sign Up to like & getrecommendations! Published in 2019 at "Value in health regional issues"
DOI: 10.1016/j.vhri.2018.12.001
Abstract: OBJECTIVES To examine the budget impact of introducing the RotaTeq® vaccine (Merck and Co Inc, West Point, PA) to the national immunization program in Iran. METHODS The pre- and postvaccine introduction costs were compared. The… read more here.
Keywords: rotavirus vaccine; budget impact; immunization; budget ... See more keywords
Inactivated rotavirus vaccine by parenteral administration induces mucosal immunity in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18973-9
Abstract: To improve the safety and efficacy of oral rotavirus vaccines, we developed an inactivated rotavirus vaccine (IRV) for parenteral administration. Since it remains unknown whether parenteral vaccination can induce mucosal immunity, we performed a comprehensive… read more here.
Keywords: immunity; mucosal immunity; rotavirus vaccine; parenteral administration ... See more keywords
Multivalent Rotavirus Vaccine and Wild-type Rotavirus Strain Shedding in Australian Infants: A Birth Cohort Study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Infectious Diseases"
DOI: 10.1093/cid/cix1022
Abstract: Background Rotavirus vaccines have reduced moderate-to-severe gastroenteritis episodes in infants and young children. Nevertheless, knowledge gaps exist concerning rotavirus vaccine shedding and vaccine impact upon mild and asymptomatic wild-type infections. Our primary objective was to… read more here.
Keywords: rotavirus vaccine; rotavirus; vaccine; wild type ... See more keywords