Integrated evaluation the antioxidant activity of epicatechin from cell dynamics.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3328
Abstract: Oxidative damage has been implicated in the pathogenesis of numerous disorders by affecting the normal functions of several tissues. Further, oxidative stress acts within cells to influence cell morphology and the behavior of cell migration.… read more here.
Keywords: rotenone; cell; damage; antioxidant ... See more keywords
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23024
Abstract: Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic diets were shown in PD.… read more here.
Keywords: response; octanoic acid; rotenone; energy redox ... See more keywords
Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7449
Abstract: Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu,… read more here.
Keywords: induced cellular; rotenone induced; cellular model; analysis ... See more keywords
Rapid recovery of macroinvertebrates in a South African stream treated with rotenone
Sign Up to like & getrecommendations! Published in 2019 at "Hydrobiologia"
DOI: 10.1007/s10750-019-3885-z
Abstract: South Africa’s Cape Fold Ecoregion supports a unique freshwater fish assemblage with many endemics. To mitigate impacts of alien invasive fishes on this unique assemblage, nature conservation authority CapeNature used rotenone to remove smallmouth bass… read more here.
Keywords: macroinvertebrates south; rotenone; treatment; south african ... See more keywords
Benefits of betanin in rotenone-induced Parkinson mice.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-021-00826-0
Abstract: The present study aimed to investigate betanin's neuroprotective effect in mice with rotenone-induced Parkinson-like motor dysfunction and neurodegeneration. Forty male ICR mice were divided into 4 groups: Sham-veh, Rot-veh, Rot-Bet100 and Rot-Bet200. Rotenone at 2.5 mg/kg/48 h… read more here.
Keywords: par compacta; rotenone; nigra par; substantia nigra ... See more keywords
Neuroprotective Role of Quercetin on Rotenone-Induced Toxicity in SH-SY5Y Cell Line Through Modulation of Apoptotic and Autophagic Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03061-8
Abstract: The detrimental impact on the food chain due to the overuse of rotenone is partly responsible for alpha-synuclein (α-syn) mediated neurotoxicity. It is hypothesized that rotenone overdose leads to cytosolic proteopathy resulting in modulation of… read more here.
Keywords: rotenone; autophagic pathways; quercetin; rotenone induced ... See more keywords
Low Molecular Weight Sulfated Chitosan: Neuroprotective Effect on Rotenone-Induced In Vitro Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9978-z
Abstract: The present investigation was an attempt to study the effect of low molecular weight sulfated chitosan (LMWSC) on in vitro rotenone model of Parkinson’s disease (PD) by evaluating cell viability, oxidative stress, mitochondrial membrane potential,… read more here.
Keywords: low molecular; rotenone; weight sulfated; molecular weight ... See more keywords
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174573
Abstract: Most treatments for Parkinson's disease (PD) focus on improving the symptoms and the dopaminergic effects; nevertheless, they cannot delay the disease progression. Diosmin (DM), a naturally occurring flavone that is obtained from citrus fruits, has… read more here.
Keywords: rotenone induced; diosmin rotenone; rotenone; parkinson disease ... See more keywords
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116581
Abstract: AIMS The aims of this study were to investigate the effect of colonic electrical stimulation (CES) on delayed colonic transit in Parkinson's disease (PD) model induced by rotenone and its possible mechanisms. MAIN METHODS Sprague-Dawley… read more here.
Keywords: rotenone; colonic electrical; colonic transit; electrical stimulation ... See more keywords
Salubrinal attenuates nitric oxide mediated PERK:IRE1α: ATF-6 signaling and DNA damage in neuronal cells
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104581
Abstract: The present study was conducted to investigate the effect of salubrinal on nitric oxide mediated endoplasmic reticulum stress signaling and neuronal apoptosis. Rotenone treatment to neuro2a cells caused significantly decreased cell viability, increased cytotoxicity, augmented… read more here.
Keywords: rotenone; perk ire1; treatment; stress ... See more keywords
Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.02.013
Abstract: HighlightsRotenone severely delayed gastric emptying, reproducing clinical gastroparesis.Rotenone altered the microbiota in the small intestine and colon.Rotenone induced colonic mucosal thickening and goblet cell hyperplasia. ABSTRACT While people are often aware of the motor symptoms… read more here.
Keywords: microbiota; rotenone; pathology; model ... See more keywords