Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7449
Abstract: Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu,… read more here.
Keywords: induced cellular; rotenone induced; cellular model; analysis ... See more keywords
Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05302-4
Abstract: A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and… read more here.
Keywords: functioning antioxidant; antioxidant defense; system rotenone; rotenone induced ... See more keywords
Neuroprotective Role of Quercetin on Rotenone-Induced Toxicity in SH-SY5Y Cell Line Through Modulation of Apoptotic and Autophagic Pathways
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DOI: 10.1007/s11064-020-03061-8
Abstract: The detrimental impact on the food chain due to the overuse of rotenone is partly responsible for alpha-synuclein (α-syn) mediated neurotoxicity. It is hypothesized that rotenone overdose leads to cytosolic proteopathy resulting in modulation of… read more here.
Keywords: rotenone; autophagic pathways; quercetin; rotenone induced ... See more keywords
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.
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DOI: 10.1016/j.ejphar.2021.174573
Abstract: Most treatments for Parkinson's disease (PD) focus on improving the symptoms and the dopaminergic effects; nevertheless, they cannot delay the disease progression. Diosmin (DM), a naturally occurring flavone that is obtained from citrus fruits, has… read more here.
Keywords: rotenone induced; diosmin rotenone; rotenone; parkinson disease ... See more keywords
Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease.
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DOI: 10.1016/j.gene.2018.01.023
Abstract: In order to uncover the remarkable pathogenic genes or molecular pathological process in Parkinson's disease (PD), we employed a microarray analysis upon the cellular PD model induced by rotenone. Compared to the control group, 2174… read more here.
Keywords: process; cellular model; rotenone induced; parkinson disease ... See more keywords
Ameliorative effects of flavonoids and polyketides on the rotenone induced Drosophila model of Parkinson's disease.
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DOI: 10.1016/j.neuro.2020.09.004
Abstract: Parkinson's disease (PD) is a movement disorder associated with the progressive loss of dopaminergic neurons (DA). PD treatment remains unsatisfactory as the current synthetic drugs in clinical use relies on managing only motor symptoms. This… read more here.
Keywords: induced drosophila; flavonoids polyketides; rotenone; parkinson disease ... See more keywords
Neuroprotective effects of Pulicaria undulata essential oil in rotenone model of parkinson's disease in rats: Insights into its anti-inflammatory and anti-oxidant effects
Sign Up to like & getrecommendations! Published in 2020 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2020.04.032
Abstract: Abstract Parkinson's disease (PD) is a neurodegenerative disorder described by severe motor symptoms involving postural imbalance, uncontrolled shake, slowness of motion and rigidity. Searching for a natural remedy for PD to overcome the common adverse… read more here.
Keywords: neuroprotective effects; rotenone; undulata essential; parkinson disease ... See more keywords
Adiponectin protects HL-1 cardiomyocytes against rotenone-induced cytotoxicity through AMPK activation.
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DOI: 10.1016/j.toxlet.2020.10.010
Abstract: The relationship between mitochondrial dysfunction or ER stress with pathogenesis of cardiovascular disease is well documented, but the crosstalk between them in cardiovascular diseases is not clear. Adiponectin (APN) is reported to become a potential… read more here.
Keywords: rotenone; ampk activation; stress; rotenone induced ... See more keywords
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
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DOI: 10.1021/acschemneuro.6b00291
Abstract: Oleracein E (OE), a tetrahydroisoquinoline possessing potent antioxidant activity, was first isolated from a traditional Chinese medicine, Portulaca oleraea L., and is hypothesized to be a neuroprotectant. In the present study, we evaluated the effects… read more here.
Keywords: disease cell; rotenone; cell animal; parkinson disease ... See more keywords
Melatonin Mitigates Rotenone-Induced Oxidative Stress and Mitochondrial Dysfunction in the Drosophila melanogaster Model of Parkinson’s Disease-like Symptoms
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DOI: 10.1021/acsomega.2c03992
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder; however, its etiology remains elusive. Antioxidants are considered to be a promising approach for decelerating neurodegenerative disease progression owing to extensive examination of the relationship… read more here.
Keywords: rotenone induced; disease; oxidative stress; drosophila ... See more keywords
Modulating effects of hesperidin on circadian pattern indices of rotenone induced redox homeostasis in clock mutant (cryb) of Drosophila melanogaster
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DOI: 10.1080/09291016.2017.1319641
Abstract: Abstract The circadian timing system controls drug metabolism and cellular processes over the 24 h period in every cell. Impaired redox homeostasis is a casual factor for a number of diseases and it is desirable… read more here.
Keywords: redox homeostasis; rotenone; treatment; rotenone induced ... See more keywords