Effect of Rotigotine vs Placebo on Cognitive Functions Among Patients With Mild to Moderate Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.10372
Abstract: This randomized clinical trial evaluates whether treatment with the dopaminergic agonist rotigotine has an effect on cognitive function in patients with mild to moderate Alzheimer disease in Italy. read more here.
Keywords: alzheimer disease; rotigotine; moderate alzheimer; effect ... See more keywords
Pharmacokinetics, Tolerability, and Bioequivalence of Two Formulations of Rotigotine in Healthy Chinese Subjects.
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DOI: 10.1016/j.clinthera.2018.05.009
Abstract: PURPOSE The pharmacokinetic (PK) profile of the rotigotine transdermal patch is well characterized in Caucasian patients with Parkinson's disease (PD) but not in Chinese subjects. This article reports the PK variables, safety, and tolerability of… read more here.
Keywords: healthy chinese; unconjugated total; rotigotine healthy; rotigotine ... See more keywords
Lipopolysaccharide/D-galactosamine-induced acute liver injury could be attenuated by dopamine receptor agonist rotigotine via regulating NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107798
Abstract: The pathological of lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced acute liver injury is similar to what is seen clinically, and be mediated by the release of pro-inflammatory mediators. A growing body of studies have shown that dopamine (DA)… read more here.
Keywords: liver injury; receptor agonist; rotigotine; dopamine receptor ... See more keywords