Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05690-x
Abstract: RATIONALE AND OBJECTIVE As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extensively studied rottlerin. Neuroscientists, however, have accumulated scarce data on the role of rottlerin in affective and… read more here.
Keywords: consolidation; inhibitory avoidance; rottlerin; memory ... See more keywords
Rottlerin upregulates DDX3 expression in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.198
Abstract: Rottlerin has been reported to exert its anti-tumor activity in various types of human cancers. However, the underlying molecular mechanism has not been fully elucidated. In the current study, we explored whether rottlerin exhibits its… read more here.
Keywords: hepatocellular carcinoma; rottlerin; expression; carcinoma cells ... See more keywords
Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Nature microbiology"
DOI: 10.1038/s41564-021-00968-y
Abstract: La Crosse virus (LACV) is a mosquito-borne orthobunyavirus that causes approximately 60 to 80 hospitalized pediatric encephalitis cases in the United States yearly. The primary treatment for most viral encephalitis, including LACV, is palliative care,… read more here.
Keywords: rottlerin; crosse virus; encephalitis; virus induced ... See more keywords
Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24066004
Abstract: The natural polyphenolic compound Rottlerin (RoT) showed anticancer properties in a variety of human cancers through the inhibition of several target molecules implicated in tumorigenesis, revealing its potential as an anticancer agent. Aquaporins (AQPs) are… read more here.
Keywords: inhibitory effect; rottlerin; unraveling aquaporin; glycerol ... See more keywords