Genomic and transcriptomic characterization of desmoplastic small round cell tumors
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.1002/gcc.22955
Abstract: Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1‐WT1 gene fusion, presumably constituting the primary driver event. Little is,… read more here.
Keywords: desmoplastic small; round cell; tumor; small round ... See more keywords
A national analysis of patterns of care and outcomes for adults diagnosed with desmoplastic small round cell tumors in the United States
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25426
Abstract: Because of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought… read more here.
Keywords: round cell; small round; patterns care; desmoplastic small ... See more keywords
Machine learning to differentiate small round cell malignant tumors and non-small round cell malignant tumors of the nasal and paranasal sinuses using apparent diffusion coefficient values
Sign Up to like & getrecommendations! Published in 2022 at "European Radiology"
DOI: 10.1007/s00330-021-08465-w
Abstract: We used radiomics feature–based machine learning classifiers of apparent diffusion coefficient (ADC) maps to differentiate small round cell malignant tumors (SRCMTs) and non-SRCMTs of the nasal and paranasal sinuses. A total of 267 features were… read more here.
Keywords: small round; cell malignant; feature; malignant tumors ... See more keywords
Small Round Blue Cell Sarcoma Other Than Ewing Sarcoma: What Should an Oncologist Know?
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DOI: 10.1007/s11864-020-00785-1
Abstract: The diagnosis of round cell sarcomas has changed rapidly over the last decade, causing much diagnostic confusion for pathologists and oncologists. The advances in diagnosis are largely due to the advent of next-generation sequencing techniques,… read more here.
Keywords: round; round cell; cell sarcomas; ewing sarcoma ... See more keywords
Head and Neck Round Cell Sarcomas: A Comparative Clinicopathologic Analysis of 2 Molecular Subsets: Ewing and CIC-Rearranged Sarcomas
Sign Up to like & getrecommendations! Published in 2017 at "Head and Neck Pathology"
DOI: 10.1007/s12105-017-0808-z
Abstract: CIC-rearranged sarcoma (CRS) is a relatively new entity defined by its pathognomonic genetic signature and undifferentiated round cell phenotype, initially grouped together with the ‘Ewing sarcoma-like tumors’. However, increasing data suggest that these tumors should… read more here.
Keywords: head neck; crs; round cell;
EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.03.020
Abstract: Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grade cytomorphology. The most common molecular alterations detected in these tumors are gene rearrangements involving EWSR1 to one of many fusion… read more here.
Keywords: ewsr1 nfatc2; nfatc2 gene; gene fusion; round cell ... See more keywords
Primary Round Cell Sarcomas of the Urinary Bladder with EWSR1 Rearrangement: A Multi-institutional Study of Thirteen Cases with Review of Literature.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.08.001
Abstract: Primary Ewing's sarcoma (ES) of the urinary bladder is a rare and aggressive small blue round cell malignant neoplasm associated primarily with translocation involving EWSR1 and FLI1 genes located in the 22nd and 11th chromosomes,… read more here.
Keywords: ewsr1 rearrangement; cell; round cell; urinary bladder ... See more keywords
Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2021.01.058
Abstract: Highlights • Intra-abdominal desmoplastic small round cell tumour is a rare tumour not previously reported in a female over the age of 50.• Disparity between radiological and histological appearances should prompt further review and investigation.•… read more here.
Keywords: cell tumour; round cell; small round; abdominal desmoplastic ... See more keywords
Can we cure patients with abdominal Desmoplastic Small Round Cell Tumor? Results of a retrospective multicentric study on 100 patients.
Sign Up to like & getrecommendations! Published in 2019 at "Surgical oncology"
DOI: 10.1016/j.suronc.2019.04.002
Abstract: BACKGROUND Despite being associated with a very poor prognosis, long-term survivors across all series of Desmoplastic Small Round Cell Tumor (DSRCT) have been reported. AIM OF THE STUDY To analyze patients 'characteristics associated with a… read more here.
Keywords: desmoplastic small; small round; cell tumor; round cell ... See more keywords
Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group
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DOI: 10.1038/s41598-020-69015-w
Abstract: To further understand the molecular pathogenesis of desmoplastic small round cell tumor (DSRCT), a fatal malignancy occurring primarily in adolescent/young adult males, we used next-generation RNA sequencing to investigate the gene expression profiles intrinsic to… read more here.
Keywords: therapeutic targets; round cell; small round; desmoplastic small ... See more keywords
Trabectedin-irinotecan, a potentially promising combination in relapsed desmoplastic small round cell tumor: report of two cases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2067706
Abstract: Abstract Effective new drugs are urgently needed for desmoplastic small round cell tumor (DSRCT), an extremely rare and aggressive disease with a generally poor prognosis. We describe two heavily-pretreated young patients with advanced-stage DSRCT given… read more here.
Keywords: cell tumor; desmoplastic small; round cell; small round ... See more keywords