Ameliorating effect of rovatirelin on the ataxia in rolling mouse Nagoya.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173271
Abstract: Rovatirelin is a newly synthetized thyrotropin-releasing hormone (TRH) analog. This study aimed to investigate the effect of rovatirelin on motor function using rolling mouse Nagoya (RMN), a mouse model of hereditary ataxia, and compare it… read more here.
Keywords: rovatirelin; effect rovatirelin; effect; mouse nagoya ... See more keywords
Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro
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DOI: 10.1080/00498254.2019.1580796
Abstract: Abstract The mass balance, pharmacokinetics and metabolism of rovatirelin were characterised in healthy male subjects after a single oral dose of [14C]rovatirelin. [14C]Rovatirelin was steadily absorbed, and the peak concentrations of radioactivity and rovatirelin were… read more here.
Keywords: balance pharmacokinetics; rovatirelin; mass balance; metabolic enzymes ... See more keywords
Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13675
Abstract: Thyrotropin‐releasing hormone (TRH) and the TRH mimetic taltirelin have been used in Japan for the treatment of spinocerebellar degeneration (SCD), a type of progressive ataxia. A TRH mimetic, rovatirelin, ameliorates ataxia symptoms in the rolling… read more here.
Keywords: rovatirelin ameliorates; motor dysfunction; motor; model ... See more keywords