Cell surface expression of human RP105 depends on N‐glycosylation of MD‐1
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DOI: 10.1002/1873-3468.14452
Abstract: For its cell surface expression, radioprotective 105 (RP105) – an orphan Toll‐like receptor – must form a complex with a soluble glycoprotein called myeloid differentiation 1 (MD‐1). The number of RP105‐negative cells is significantly increased… read more here.
Keywords: cell surface; surface expression; rp105;
Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis
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DOI: 10.1172/jci.insight.160684
Abstract: Activation of TLR4 by its cognate damage-associated molecular patterns (DAMPs) elicits potent profibrotic effects and myofibroblast activation in systemic sclerosis (SSc), while genetic targeting of TLR4 or its DAMPs in mice accelerates fibrosis resolution. To… read more here.
Keywords: tlr4 homolog; tlr4; rp105; ssc skin ... See more keywords
RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways
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DOI: 10.3892/ijmm.2018.3538
Abstract: The Toll-like receptor 4 (TLR4) signal pathway-induced inflammation is considered to be a crucial link to myocardial ischemia reperfusion injury (MIRI). Our previous study proved that radioprotective 105 kDa protein (RP105), a negative regulator of… read more here.
Keywords: rp105; myocardial ischemia; reperfusion; tlr4 trif ... See more keywords