Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.006
Abstract: Esophageal cancer (EC) is the 6th leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1,… read more here.
Keywords: orai1 mediated; store operated; rp4010; cancer ... See more keywords
Abstract B128: Efficacy of RP4010, a calcium release-activated calcium (CRAC) inhibitor, in preclinical models of DLBCL
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b128
Abstract: Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive, rapidly growing type of lymphoma that comprises 30-40% of NHL cases. Chemotherapy remains the most widely used treatment for DLBCL, thereby necessitating the need to develop… read more here.
Keywords: models dlbcl; efficacy; rp4010; preclinical models ... See more keywords