The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
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DOI: 10.1073/pnas.2303479120
Abstract: The human tumor suppressor Ring finger protein 20 (RNF20)-mediated histone H2B monoubiquitination (H2Bub) is essential for proper chromosome segregation and DNA repair. However, what is the precise function and mechanism of RNF20-H2Bub in chromosome segregation… read more here.
Keywords: rpa rnf20; chromosome segregation; repair;