Ultra‐Fast UPLC‐MS/MS Method for the Ripretinib Quantification in the HLMs Matrix With Metabolic Stability Assessment: In‐Silico Study for Toxic Alerts and the Metabolic Lability
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DOI: 10.1002/ardp.70130
Abstract: Ripretinib (QINLOCK) is a broad‐spectrum, orally‐administered, switch‐controlled kinase inhibitor that got FDA approval in May 2020 for the treatment of advanced gastrointestinal stromal tumors (GIST) in adult patients who have formerly had treatment with three or… read more here.
Keywords: hlms matrix; stability; metabolic stability; silico ... See more keywords
The Least Biased d to rpb-rpb to d Conversion Formula Combinations for the Meta-Analysis of Studies Using the Two Independent-Groups Design.
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DOI: 10.1177/00332941211065952
Abstract: In a meta-analysis of ds, the utility of converting d to a point-biserial correlation (rpb), correcting rpb for study artifacts, and then converting rpb back to d depends on how accurately the d to rpb-rpb… read more here.
Keywords: bias; conversion; formula combinations; rpb ... See more keywords
Critical Hazards Identification and Prevention of Cascading Escalator Accidents at Metro Rail Transit Stations
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DOI: 10.3390/ijerph17103400
Abstract: Escalator accidents not only happen frequently but also have cascading effects. The purpose of this study is to block the formation of cascading accident networks by identifying and preventing critical hazards. A modified five-step task-driven… read more here.
Keywords: rpb; critical hazards; escalator accidents; cascading escalator ... See more keywords