Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24525
Abstract: Background: The retinal pigment epithelium (RPE) is a specialized monolayer of epithelial cells that forms a tight barrier surrounding the neural retina. RPE cells are indispensable for mature photoreceptor renewal and survival, yet how the… read more here.
Keywords: neural retina; expansion; epithelium; retinal pigment ... See more keywords
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)
Sign Up to like & getrecommendations! Published in 2020 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.23288
Abstract: The thermal stimulation therapy of the retinal pigment epithelium (TSR) is a sublethal laser technique for thermal stimulation of the retinal pigment epithelium (RPE)‐Bruch's membrane (BrM)‐complex. The aim of this study was to investigate the… read more here.
Keywords: thermal stimulation; retinal pigment; pigment epithelium; rpe ... See more keywords
Cell-Based Therapies for Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-66014-7_11
Abstract: Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. The pathogenesis of AMD involves dysfunction and loss of the retinal pigment epithelium (RPE), a monolayer of cells that provide nourishment and functional support… read more here.
Keywords: age related; related macular; cell based; degeneration ... See more keywords
Bruch's Membrane and the Choroid in Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-66014-7_4
Abstract: A healthy choroidal vasculature is necessary to support the retinal pigment epithelium (RPE) and photoreceptors, because there is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex.… read more here.
Keywords: age related; bruch membrane; blood; rpe ... See more keywords
Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1506-8
Abstract: A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1)… read more here.
Keywords: connexin43 mimetic; zonula occludens; ct1; rpe pathophysiology ... See more keywords
Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01753-5
Abstract: NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We tested selective NLRP3 inhibitors… read more here.
Keywords: human murine; inflammasome activation; nlrp3 inhibitors; activation ... See more keywords
Disease-causing mutations associated with bestrophinopathies promote apoptosis in retinal pigment epithelium cells
Sign Up to like & getrecommendations! Published in 2020 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-020-04636-5
Abstract: Purpose Best vitelliform macular dystrophy (BVMD) and autosomal recessive bestrophinopathy (ARB) are two kinds of bestrophinopathies which are caused by BEST1 mutations and characterized by accumulation of lipofuscin-like materials on the retinal pigment epithelium cell-photoreceptor… read more here.
Keywords: s142g a146t; apoptosis; rpe cells; pigment epithelium ... See more keywords
Effects of nitrogen fertilization on the rhizosphere priming
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DOI: 10.1007/s11104-021-04872-6
Abstract: It is known that nitrogen (N) input modulates the rhizosphere priming effect (RPE); however, the magnitude and driving mechanisms of priming under increasing rates of fertilizer application remain unclear. 15N-urea (control, 75 (N75), 150 (N150),… read more here.
Keywords: microbial imbalance; effects nitrogen; nitrogen fertilization; rpe ... See more keywords
The Use of Ratings of Perceived Exertion in Children and Adolescents: A Scoping Review
Sign Up to like & getrecommendations! Published in 2020 at "Sports Medicine"
DOI: 10.1007/s40279-020-01374-w
Abstract: In adults, ratings of perceived exertion (RPE) can be used to predict maximal oxygen uptake, estimate time to exhaustion, assess internal training load and regulate exercise intensity. However, the utility of RPE in children is… read more here.
Keywords: scoping review; review; ratings perceived; exercise ... See more keywords
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2016.11.016
Abstract: No treatments exist to effectively treat many retinal diseases. Retinal pigmented epithelium (RPE) and neural retina can be generated from human embryonic stem cells/induced pluripotent stem cells (hESCs/hiPSCs). The efficacy of current protocols is, however,… read more here.
Keywords: retinal tissue; rgd alginate; tissue; stem cells ... See more keywords
Retinal Pigment Epithelium Humps in High Myopia.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.07.013
Abstract: PURPOSE To report on the presence of retinal pigment epithelium (RPE) humps in high myopia, and to describe the distinctive features from pathologic RPE detachments and choroidal neovascularizations (CNVs). DESIGN Retrospective cross-sectional study. METHODS Charts… read more here.
Keywords: high myopia; rpe humps; pigment epithelium; humps high ... See more keywords