Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111957
Abstract: Oxidative stress-induced retinal pigment epithelial cell (RPE) dysfunction is a primary contributing factor to early dry age-related macular degeneration (AMD). Oxidative injury to the retina may promote extracellular vesicles (EVs) released from RPE. In this… read more here.
Keywords: rpe cell; pigment epithelial; rpe cells; retinal pigment ... See more keywords
Disruption of retinal pigment epithelial cell properties under the exposure of cotinine
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03283-x
Abstract: Cigarette smoking is a major risk factor for age-related macular degeneration (AMD), in which progressive retinal pigment epithelial (RPE) cell degeneration is a major pathological change. Nicotine is a major biologically active component in cigarette… read more here.
Keywords: rpe cell; pigment epithelial; cotinine; retinal pigment ... See more keywords
ROCK Inhibitor-Induced Promotion of Retinal Pigment Epithelial Cell Motility during Wound Healing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ophthalmology"
DOI: 10.1155/2019/9428738
Abstract: Purpose No standard therapy for RPE tear, a complication of neovascular age-related macular degeneration, exists even though RPE tears cause severe vision loss, and promotion of cell proliferation and/or migration could be a candidate RPE… read more here.
Keywords: wound healing; cell motility; motility wound; rpe cell ... See more keywords
Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059056
Abstract: ABSTRACT The human retinal pigment epithelial RPE-1 cell line immortalized with hTERT retains a stable karyotype with a modal chromosome number of 46 and has been widely used to study physiological events in human cell… read more here.
Keywords: cell line; cre; cell; rpe cell ... See more keywords
Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00888
Abstract: The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment… read more here.
Keywords: rpe cell; receptor 51e2; migration proliferation; odorant receptor ... See more keywords
Pleiotropic Roles of Scavenger Receptors in Circadian Retinal Phagocytosis: A New Function for Lysosomal SR-B2/LIMP-2 at the RPE Cell Surface
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073445
Abstract: The retinal phagocytic machinery resembles the one used by macrophages to clear apoptotic cells. However, in the retina, the permanent contact between photoreceptor outer segments (POS) and retinal pigment epithelial (RPE) cells requires a tight… read more here.
Keywords: cd36; limp; rpe; phagocytosis ... See more keywords
Lipofuscin-Mediated Photic Stress Induces a Dark Toxic Effect on ARPE-19 Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012234
Abstract: Lipofuscin granules from retinal pigment epithelium (RPE) cells contain bisretinoid fluorophores, which are photosensitizers and are phototoxic to cells. In the presence of oxygen, bisretinoids are oxidized to form various products, containing aldehydes and ketones,… read more here.
Keywords: cell; arpe; rpe; toxic effect ... See more keywords