An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
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DOI: 10.1016/j.molcel.2017.07.023
Abstract: Poly-ubiquitin chains direct protein substrates to the 26S proteasome, where they are removed by the deubiquitinase Rpn11 during ATP-dependent substrate degradation. Rapid deubiquitination is required for efficient degradation but must be restricted to committed substrates that… read more here.
Keywords: switch; rpn11; 26s proteasome; aaa motor ... See more keywords